- Poster presentation
- Open Access
Lipid-enriched and protein-enriched enteral nutrition limits inflammation in a human endotoxemia model
© Kox et al. 2011
- Published: 1 March 2011
- Fast Subject
- Fast Group
- Immunomodulatory Potential
- Enteral Administration
Enteral administration of lipid-enriched nutrition was previously shown to attenuate inflammation and organ damage via a cholecystokinin-mediated vagovagal reflex in animal studies. The current proof-of-principle study investigates the immunomodulatory potential of enteral lipid-enriched and protein-enriched nutrition during experimental human endotoxemia.
After an overnight fast, 18 healthy male subjects received an intravenous bolus of Escherichia coli lipopolysaccharide (LPS; 2 ng/kg). Subjects in the fasted group (n = 6) were deprived of food throughout the study, while subjects in the intervention groups were fed either enriched (n = 6) or isocaloric control nutrition (n = 6) via a nasojejunal tube, starting 1 hour prior to LPS administration until 6 hours afterwards.
The current study establishes the anti-inflammatory potential of enriched nutrition in humans. The immediate anti-inflammatory effect of enriched nutrition suggests that the beneficial effects are mediated via a cholecystokinin-dependent vagovagal reflex. Enteral administration of enriched nutrition is a promising intervention to modulate the immune response in the early course of systemic inflammation.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.