- Poster presentation
- Open Access
Bilirubin and carboxy-hemoglobin concentrations in critically ill patients: prognostic significance of free heme metabolites
© Morimatsu et al. 2011
- Published: 1 March 2011
- Prognostic Significance
- Heme Protein
- Physiological Assessment
- Free Heme
Serum bilirubin is routinely measured in the ICU. Physiologically, bilirubin is one of three heme metabolites such as iron and carbon monoxide (CO), but this fact is almost completely ignored in our daily physiological assessments. In this study, we examined the prognostic significance of these two heme metabolites (T-Bil and CO-Hb) in general ICU populations.
We retrospectively studied 723 patients with 12,458 blood gas measurements. Finally, we analyzed paired samples of 1,882 blood gas measurements and laboratory results from 491 ICU patients. We specifically assessed the prognostic significance of serum T-Bil and CO-Hb and their combination.
Serum T-Bil values were significantly higher in the nonsurvivors than the survivors. Prognostic significance of T-Bil significantly improved when taking into account the CO-Hb levels. These results imply that, even in the general ICU patients, metabolites of heme protein had prognostic significance and importance.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.