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- Open Access
Metformin increases skeletal muscle lactate production in pigs: a microdialysis study
© Protti et al. 2011
- Published: 1 March 2011
- Skeletal Muscle
- Continuous Infusion
- Lactate Level
Lactic acidosis during metformin intoxication is mainly attributed to impaired hepatic lactate clearance . The aim of this present work was to clarify whether metformin at high dose also increases skeletal muscle lactate production.
Reverse microdialysis was used in six healthy, sedated and mechanically ventilated pigs, equipped with two skeletal muscle catheters (CMA Microdialysis AB, Sweden). Following a baseline recording, a continuous infusion of saline (control) or metformin diluted in saline (1 mol/l) began. Outflow lactate concentration was measured every 3 hours, up to 12 hours.
In skeletal muscle, a high dose of metformin increases interstitial lactate levels, a finding consistent with local lactate overproduction.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.