Paracetamol-induced skin blood flow and blood pressure changes
© Boyle et al. 2011
Published: 1 March 2011
Twenty-nine adults, 58 ± 15 years, were treated with enteral or intravenous paracetamol for fever. Forty-one percent (n = 12) were medical, 31% (n = 9) surgical, and 28% (n = 8) neurological. APACHE II score was 17.2 ± 8.3. Frequency domain analyses of the laser Doppler flowmetry (LDF) waveforms of two patients were undertaken. Both patients (A and B) had good LDF waveforms, both increased skBF whilst BP fell in patient B.
Paracetamol induced increases in skBF consistent with its antipyretic action. Changes in PSD and wavelet analysis were consistent with cutaneous vasodilation.
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