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Incidence, risk factors, and impact on mortality of status epilepticus in sepsis in the United States

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Critical Care201115 (Suppl 1) :P328

  • Published:


  • Status Epilepticus
  • Hospital Mortality
  • Septic Patient
  • Clinical Modification
  • Metabolic Dysfunction


We sought to determine the epidemiology of status epilepticus (SE), prevalence of risk factors and impact on hospital mortality in sepsis in the United States. We hypothesized that SE would be associated with increased mortality.


Data were derived from the National Inpatient Sample from 1998 to 2008. We included patients older than 18 years, with a primary diagnosis of sepsis and SE. Definitions were based on the International Classification of Diseases, Ninth Revision, Clinical Modification Codes (ICD-9). Adjusted incidence rates, prevalence odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Multivariate logistical models assessed for the impact of SE on hospital mortality.


We identified 7,672,551 admissions with diagnosis of sepsis and 7,619 with SE from 1998 to 2008. The population-adjusted rate of sepsis increased from 72/100,000 in 1998 to 250/100,000 in 2008. In septic patients, SE was more common in older patients, in women than men, in urban academic centers than rural centers, in those with respiratory dysfunction and metabolic dysfunction. Total in-hospital mortality fell from 20% in 1998 to 18.1% in 2008, yet the number of deaths increased over the study period. Mortality was highest among SE (OR = 1.7; 95% CI = 1.4 to 1.9) (Figure 1), older patients, men, those with respiratory dysfunction, cardiovascular dysfunction, hematologic dysfunction, metabolic dysfunction, renal dysfunction and hepatic encephalopathy.
Figure 1
Figure 1

In-hospital mortality in septic patients.


Our study demonstrates the incidence of SE in sepsis is increasing. Despite a decline in sepsis-related mortality, the presence of SE doubles the risk of in-hospital death. Further study is needed to determine whether detection and treatment of SE will impact mortality.

Authors’ Affiliations

Thomas Jefferson University, Philadelphia, PA, USA


  1. Oddo M, et al.: Crit Care Med. 2009, 37: 2051-2056. 10.1097/CCM.0b013e3181a00604View ArticlePubMedGoogle Scholar
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© Urtecho et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.