- Poster presentation
- Open Access
Multicenter trial of a perioperative protocol to reduce mortality in critically ill patients with peptic ulcer perforation: the PULP trial
- M Hylander Møller1
© Møller. 2011
- Published: 1 March 2011
- Intervention Group
- Relative Risk
- Demographic Characteristic
- Emergency Medicine
- Risk Reduction
The aim of the present intervention study was to evaluate the effect of a multimodal and multidisciplinary perioperative care protocol on mortality in patients with peptic ulcer perforation (PPU). Sepsis is frequent and a leading cause of death in PPU patients, and morbidity and mortality is substantial [1, 2].
An externally controlled multicenter trial using historical and concurrent national controls in seven gastrointestinal departments in Denmark. Participants were 117 consecutive patients surgically treated for gastric or duodenal PPU between 1 January 2008 and 31 December 2009. The intervention was a multimodal and multidisciplinary perioperative care protocol based on the Surviving Sepsis Campaign. The main outcome measure was 30-day mortality.
The 30-day mortality in patients with PPU was reduced by more than one-third after the implementation of a multimodal and multidisciplinary perioperative care protocol based on the Surviving Sepsis Campaign, as compared with conventional treatment.
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