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Prognostic value of routinely assessed serum biomarkers in septic shock


The objective of this study was to assess the usefulness of routinely admission measured biomarkers.


From a sample of 256 patients enrolled between October 2009 and November 2010, 193 had sepsis and 63 had septic shock based on the ACCP/SCCM criteria, and for each of them we measured reactive protein C (RPC), total cholesterol, protein C activity (PC), albumin, arterial lactate and the levels of IL-6 at admission.


Levels of lactate, IL-6 and PC (< 40%) showed the best accuracy for prediction mortality in all of the study patients as much as in the arm of the septic shock patients (AUROC 0.76; 0.80; 0.75, respectively; and AUROC 0.86; 0.86; 0.75, respectively). See Table 1.

Table 1 (abstract P274)


Biomarkers at ICU admission revealed different accuracies in predicting septic shock mortality. Maximal lactate, mean IL-6 and minimum PC levels were associated with the higher mortality found in this ICU population.


  1. Marshal JC, International Sepsis Forum: Biomarkers of sepsis. Crit Care Med 2009, 37: 2290-2298. 10.1097/CCM.0b013e3181a02afc

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Lafuente, E., Viegas, E., Filipe, E. et al. Prognostic value of routinely assessed serum biomarkers in septic shock. Crit Care 15 (Suppl 1), P274 (2011).

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  • Cholesterol
  • Lactate
  • Total Cholesterol
  • Septic Shock
  • Good Accuracy