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  • Poster presentation
  • Open Access

Prognostic value of routinely assessed serum biomarkers in septic shock

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Critical Care201115 (Suppl 1) :P274

https://doi.org/10.1186/cc9694

  • Published:

Keywords

  • Cholesterol
  • Lactate
  • Total Cholesterol
  • Septic Shock
  • Good Accuracy

Introduction

The objective of this study was to assess the usefulness of routinely admission measured biomarkers.

Methods

From a sample of 256 patients enrolled between October 2009 and November 2010, 193 had sepsis and 63 had septic shock based on the ACCP/SCCM criteria, and for each of them we measured reactive protein C (RPC), total cholesterol, protein C activity (PC), albumin, arterial lactate and the levels of IL-6 at admission.

Results

Levels of lactate, IL-6 and PC (< 40%) showed the best accuracy for prediction mortality in all of the study patients as much as in the arm of the septic shock patients (AUROC 0.76; 0.80; 0.75, respectively; and AUROC 0.86; 0.86; 0.75, respectively). See Table 1.
Table 1

(abstract P274)

 

Septic shock

No septic shock

P value

No sepsis

SAPS II/mortality (%)

53.9 ± 19.1/52

35.1 ± 14.4/10

0.0001

30.2 ± 16/6.6

RPC

208 ± 115

185 ± 118

0.83

108 ± 105

Protein C

35.5 ± 17.8

56.1 ± 24

0.0001

65.8 ± 32.8

Albumin

2 ± 0.2

1.8 ± 0.6

0.5

2.3 ± 0.6

Lactate

4.5 ± 2.9

2.6 ± 2.6

0.0001

1.9 ± 1.8

Total cholesterol

77.8 ± 54

97.1 ± 48

0.02

136 ± 81

IL-6

42,252 ± 9,131

2,732 ± 725

0.001

1,434 ± 586

Conclusions

Biomarkers at ICU admission revealed different accuracies in predicting septic shock mortality. Maximal lactate, mean IL-6 and minimum PC levels were associated with the higher mortality found in this ICU population.

Authors’ Affiliations

(1)
Centro Hospitalar Tamega e Sousa, Penafiel, Portugal

References

  1. Marshal JC, International Sepsis Forum: Biomarkers of sepsis. Crit Care Med 2009, 37: 2290-2298. 10.1097/CCM.0b013e3181a02afcView ArticleGoogle Scholar

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