Volume 15 Supplement 1

31st International Symposium on Intensive Care and Emergency Medicine

Open Access

Prognostic value of routinely assessed serum biomarkers in septic shock

  • E Lafuente1,
  • E Viegas1,
  • E Filipe1,
  • E Tomas1,
  • M Fernandes1,
  • J Gomes da Silva1,
  • F Santos1,
  • F Moura1,
  • R Lopes1,
  • P Santos1,
  • N Ribeiro1 and
  • I Terra1
Critical Care201115(Suppl 1):P274

https://doi.org/10.1186/cc9694

Published: 1 March 2011

Introduction

The objective of this study was to assess the usefulness of routinely admission measured biomarkers.

Methods

From a sample of 256 patients enrolled between October 2009 and November 2010, 193 had sepsis and 63 had septic shock based on the ACCP/SCCM criteria, and for each of them we measured reactive protein C (RPC), total cholesterol, protein C activity (PC), albumin, arterial lactate and the levels of IL-6 at admission.

Results

Levels of lactate, IL-6 and PC (< 40%) showed the best accuracy for prediction mortality in all of the study patients as much as in the arm of the septic shock patients (AUROC 0.76; 0.80; 0.75, respectively; and AUROC 0.86; 0.86; 0.75, respectively). See Table 1.
Table 1

(abstract P274)

 

Septic shock

No septic shock

P value

No sepsis

SAPS II/mortality (%)

53.9 ± 19.1/52

35.1 ± 14.4/10

0.0001

30.2 ± 16/6.6

RPC

208 ± 115

185 ± 118

0.83

108 ± 105

Protein C

35.5 ± 17.8

56.1 ± 24

0.0001

65.8 ± 32.8

Albumin

2 ± 0.2

1.8 ± 0.6

0.5

2.3 ± 0.6

Lactate

4.5 ± 2.9

2.6 ± 2.6

0.0001

1.9 ± 1.8

Total cholesterol

77.8 ± 54

97.1 ± 48

0.02

136 ± 81

IL-6

42,252 ± 9,131

2,732 ± 725

0.001

1,434 ± 586

Conclusions

Biomarkers at ICU admission revealed different accuracies in predicting septic shock mortality. Maximal lactate, mean IL-6 and minimum PC levels were associated with the higher mortality found in this ICU population.

Authors’ Affiliations

(1)
Centro Hospitalar Tamega e Sousa

References

  1. Marshal JC, International Sepsis Forum: Biomarkers of sepsis. Crit Care Med 2009, 37: 2290-2298. 10.1097/CCM.0b013e3181a02afcView ArticleGoogle Scholar

Copyright

© Lafuente et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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