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Honokiol attenuates the severity of acute pancreatitis-associated lung injury by acceleration of acinar cell apoptosis

  • 1
Critical Care201115 (Suppl 1) :P254

  • Published:


  • Pancreatitis
  • Lung Injury
  • Acute Pancreatitis
  • Acute Lung Injury
  • Cytokine Level


Acute pancreatitis (AP) is a complicated immunological response that leads to multiple organ failure. Apoptosis is a beneficial form of cell death in AP. Acute lung injury is the most severe complication. Honokiol (HK) is a component of Asian herbal teas. It displays an anti-inflammatory and apoptotic induction effect. In the experiments, we investigated the therapeutic efficacy of HK in AP.


Adult BALB/c mice were divided into one control and five AP groups. Mice received six injections of cerulein at 1-hour intervals then on intraperitoneal injection (i.p.) of LPS for the induction of AP. Mice in the other groups had injections of cerulein and LPS as described above, but also received an i.p. of the different doses of HK 10 minutes after the first cerulein injection. Cytokine levels for the early and late inflammatory markers were obtained at 3 hours and 24 hours after the end of experiments.


HK protected against the severity of AP in serum amylase/lipase, TNFα, IL-6, HMGB1, and pancreas and lung pathological injury (Figure 1A). Acinar cell apoptosis was increased in the pancreas. Treatment with HK caused markedly increased acinar cell apoptosis (Figure 1B).
Figure 1
Figure 1

(abstract P254)


HK attenuates the severity of AP and lung injury by acceleration of acinar cell apoptosis.

Authors’ Affiliations

National Taiwan University, Taipei, Taiwan


  1. Fried LE, et al.: Antioxid Redox Signal. 2009, 11: 1139-1148. 10.1089/ars.2009.2440PubMed CentralView ArticlePubMedGoogle Scholar


© Weng. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.