- Poster presentation
- Open Access
Influence of body mass index on the innate immune response during human endotoxemia
- R Van der Pluijm1
© Van der Pluijm. 2011
- Published: 1 March 2011
- Body Mass Index
- Innate Immune Response
- High Body Mass Index
- Lower Body Mass Index
- Microbial Pathogen
Accumulating data suggest a protective effect of obesity in the case of severe infections. Higher baseline levels of the proinflammatory cytokine TNFα as well as more pronounced TNFα release following whole blood stimulation with endotoxin are reported in patients with a higher body mass index (BMI). This more pronounced proinflammatory response in obese patients may enable a rapid and more effective clearance of microbial pathogens. The effect of the body mass index on the innate immune response in vivo has not been assessed.
The immune response and BMI of 69 healthy subjects that were included in several experimental endotoxemia studies were analyzed. Endotoxemia was induced by the administration of 2 ng/kg Escherichia coli lipopolysaccharide. Concentrations of TNFα and IL-10 were serially determined (Luminex assay). Areas under the curve of cytokine levels were calculated and analyzed with unpaired t tests. All data are expressed as mean ± SEM of n subjects.
This study is the first to demonstrate that a higher BMI is associated with a shift in the pro/anti-inflammatory balance towards a more pronounced proinflammatory immune response in humans in vivo.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.