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Effects of tigecycline and doxycycline in porcine endotoxemia

Introduction

Tigecycline, the first drug in a new class of antibiotics, the glycylcyclines, is used in the treatment of severe abdominal and connective tissue infections. Tetracyclines, having a structure-activity relationship with tigecycline, exert anti-inflammatory effects [1]. Some laboratory studies suggest that tigecycline may have anti-inflammatory properties in sepsis, but this has not previously been explored in a large animal integrative intensive care model.

Methods

Eighteen piglets weighting 25.0 ± 2.2 (mean ± SD) were randomized to receive tigecycline 100 mg, doxycycline 200 mg or placebo and subjected to 6 hours of endotoxin infusion of 2 μg/kg/hour. We measured inflammatory, hemodynamic and respiratory variables.

Results

TNFα was lower in the doxycycline group compared with the tigecycline and placebo groups during the experiment 0 to 6 hours (P < 0.05). The mean arterial pressure decline from baseline was greater during the experiment in the placebo group compared with the tigecycline group 0 to 6 hours (P < 0.05), but not the doxycycline group.

Conclusions

Doxycycline demonstrated anti-inflammatory properties. Tigecycline counteracted emerging circulatory deterioration without affecting the proinflammatory cytokine response in this model.

References

  1. 1.

    Milano S, et al.: Antimicrob Agents Chemother. 1997, 41: 117-121.

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Correspondence to M Von Seth.

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Von Seth, M., Sjölin, J., Larsson, A. et al. Effects of tigecycline and doxycycline in porcine endotoxemia. Crit Care 15, P236 (2011). https://doi.org/10.1186/cc9656

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Keywords

  • Placebo Group
  • Tetracycline
  • Proinflammatory Cytokine
  • Doxycycline
  • Tissue Infection