- Poster presentation
- Open Access
Effects of tigecycline and doxycycline in porcine endotoxemia
© Von Seth et al. 2011
- Published: 1 March 2011
- Placebo Group
- Proinflammatory Cytokine
- Tissue Infection
Tigecycline, the first drug in a new class of antibiotics, the glycylcyclines, is used in the treatment of severe abdominal and connective tissue infections. Tetracyclines, having a structure-activity relationship with tigecycline, exert anti-inflammatory effects . Some laboratory studies suggest that tigecycline may have anti-inflammatory properties in sepsis, but this has not previously been explored in a large animal integrative intensive care model.
Eighteen piglets weighting 25.0 ± 2.2 (mean ± SD) were randomized to receive tigecycline 100 mg, doxycycline 200 mg or placebo and subjected to 6 hours of endotoxin infusion of 2 μg/kg/hour. We measured inflammatory, hemodynamic and respiratory variables.
TNFα was lower in the doxycycline group compared with the tigecycline and placebo groups during the experiment 0 to 6 hours (P < 0.05). The mean arterial pressure decline from baseline was greater during the experiment in the placebo group compared with the tigecycline group 0 to 6 hours (P < 0.05), but not the doxycycline group.
Doxycycline demonstrated anti-inflammatory properties. Tigecycline counteracted emerging circulatory deterioration without affecting the proinflammatory cytokine response in this model.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.