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  • Poster presentation
  • Open Access

Effects of tigecycline and doxycycline in porcine endotoxemia

  • 1,
  • 2,
  • 2,
  • 1 and
  • 1
Critical Care201115 (Suppl 1) :P236

https://doi.org/10.1186/cc9656

  • Published:

Keywords

  • Placebo Group
  • Tetracycline
  • Proinflammatory Cytokine
  • Doxycycline
  • Tissue Infection

Introduction

Tigecycline, the first drug in a new class of antibiotics, the glycylcyclines, is used in the treatment of severe abdominal and connective tissue infections. Tetracyclines, having a structure-activity relationship with tigecycline, exert anti-inflammatory effects [1]. Some laboratory studies suggest that tigecycline may have anti-inflammatory properties in sepsis, but this has not previously been explored in a large animal integrative intensive care model.

Methods

Eighteen piglets weighting 25.0 ± 2.2 (mean ± SD) were randomized to receive tigecycline 100 mg, doxycycline 200 mg or placebo and subjected to 6 hours of endotoxin infusion of 2 μg/kg/hour. We measured inflammatory, hemodynamic and respiratory variables.

Results

TNFα was lower in the doxycycline group compared with the tigecycline and placebo groups during the experiment 0 to 6 hours (P < 0.05). The mean arterial pressure decline from baseline was greater during the experiment in the placebo group compared with the tigecycline group 0 to 6 hours (P < 0.05), but not the doxycycline group.

Conclusions

Doxycycline demonstrated anti-inflammatory properties. Tigecycline counteracted emerging circulatory deterioration without affecting the proinflammatory cytokine response in this model.

Authors’ Affiliations

(1)
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
(2)
Department of Medical Sciences, Uppsala University, Uppsala, Sweden

References

  1. Milano S, et al.: Antimicrob Agents Chemother. 1997, 41: 117-121.PubMed CentralPubMedGoogle Scholar

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