- Poster presentation
- Open Access
Polyhexanide anti-infective coating of central venous catheters in prevention of catheter colonization and bloodstream infection: Study HC-G-H-0507
© Krikava et al. 2011
- Published: 1 March 2011
- Central Venous Catheter
- Insertion Site
- Colonization Rate
- Bloodstream Infection
Internal and external anti-infective coating of central venous catheters (CVCs) may reduce the rate of catheter colonization (CC) and bloodstream infection (BSI) . Our objective was to evaluate the efficacy of a protective nonleaching polyhexanide coating on the rate of CC and BSI in ICU settings.
A prospective, randomized, controlled, double-blind clinical trial was performed on multidisciplinary ICUs of two university hospitals in the Czech Republic between 2005 and 2010. A total of 680 patients were randomized to receive either coated CVC (Certofix® protect; B. Braun Melsungen AG) or standard CVC (Certofix®; B. Braun Melsungen AG). Primary objectives were the difference of the incidence of both CC and BSI between groups. Catheter colonization was defined as the growth of >1,000 colony-forming units using the sonication method.
Our results suggest that the use of external/internal polyhexanide-coated CVCs is associated with significant reduction of BSI but not with the reduction of colonization rate.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.