Skip to main content
  • Poster presentation
  • Open access
  • Published:

Septic shock in a cohort of patients from the northeast of France: a preliminary epidemiological study, EPISS group


Incidence of septic shock in France ranges from 8 to 10% among patients admitted to intensive care. Mortality at 28 days is 55 to 60% [1]. We aimed to investigate epidemiology, treatment and mortality of patients with septic shock further to the Surviving Sepsis Campaign international guidelines [2].


A prospective, multicentre, observational cohort study supported by the Collège Interrégional des Réanimateurs du Nord-Est (CIRNE) including 14 ICUs in 10 university or nonacademic hospitals. Inclusion criteria were: patients presenting with documented/suspected infection requiring initiation of vasopressor amines despite adequate vascular filling, with at least one of the following hypoperfusion criteria: metabolic acidosis (base excess ≥5 mEq/l or alkaline reserve <18 mEq/l or lactate ≥2.5 mmol/l); oliguria/renal insuf-ficiency (< 0.5 ml/kg/hour for 3 hours or elevation >50% of baseline creatinine); or hepatic dysfunction (AST or ALT >500 IU/l or bilirubin >20 mg/l (34 μmol/l)). Quality control was performed by the Dijon Clinical Investigation Center (INSERM).


Mean inclusion was 80 patients/month for all centres. We analysed the first 350 patients with validated files of 876 patients included up to 1 December 2010. Mean age was 69 ± 13 years, 66% men. Indication for admission was medical in 84%. Mean SAPS II score was 60.9 ± 21.8, mean SOFA score at time of shock was 11.7 ± 3.5. Sepsis was mainly of pulmonary (45.7%), digestive (19.4%), or urinary (11.1%) origin, with 23.8% other causes. Sepsis was mainly community-acquired (63.7%) and was documented in 67% (234/350), of which 53.4% were Gram-negative bacilli, 30.3% Gram-positive cocci and 16.3% others. Replacement techniques used were: invasive mechanical ventilation (82.6%), continuous dialysis (31.1%) and discontinuous dialysis (19.7%). Activated protein C was used in 17 patients (5%) and hydrocortisone hemisuccinate in 238 (68.6%). Mortality was 49.1% in intensive care, 58.8% in-hospital.


Our findings raise hope of improved knowledge of epidemiology and management of septic shock in intensive care patients, and should have a beneficial effect on prognosis.


  1. Annane D: Am J Respir Crit Care Med. 2003, 168: 165. 10.1164/rccm.2201087

    Article  PubMed  Google Scholar 

  2. Dellinger R: Crit Care Med. 2008, 36: 296. 10.1097/01.CCM.0000298158.12101.41

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

Quenot, J., Pavon, A., Binquet, C. et al. Septic shock in a cohort of patients from the northeast of France: a preliminary epidemiological study, EPISS group. Crit Care 15 (Suppl 1), P212 (2011).

Download citation

  • Published:

  • DOI: