Skip to main content

Strain threshold for ventilator-induced lung injury

Introduction

Unphysiological lung strain (tidal volume/functional residual capacity, TV/FRC) may cause ventilator-induced lung injury (VILI) [1]. Whether VILI develops proportionally to the applied strain or only above a critical threshold remains unknown.

Methods

In 20 healthy, mechanically ventilated pigs, FRC and lung weight were measured by computed tomography. Animals were then ventilated for up to 54 hours with a TV set to produce a predetermined strain. At the end, lung weight was measured with a balance. VILI was defined as final lung weight exceeding the initial one.

Results

Lung weight either did not increase at all (no-VILI group; lung weight change -73 ± 42 g, n = 9) or markedly augmented (VILI group; 264 ± 80 g, n = 11). In the two groups, strain was 1.38 ± 0.68 and 2.16 ± 0.50 (P < 0.01), respectively. VILI occurred only when lung strain reached or exceeded a critical threshold, between 1.5 and 2.1 (Figure 1).

Figure 1
figure1

abstract

Conclusions

In animals with healthy lungs VILI only occurs when lung strain exceeds a critical threshold.

References

  1. 1.

    Gattinoni L, Carlesso E, Cadringher P, et al.: Physical and biological triggers of ventilator-induced lung injury and its prevention [review]. Eur Respir J 2003,22(Suppl 47):15s-25s.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to A Santini.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Santini, A., Protti, A., Cressoni, M. et al. Strain threshold for ventilator-induced lung injury. Crit Care 15, P198 (2011). https://doi.org/10.1186/cc9618

Download citation

Keywords

  • Public Health
  • Compute Tomography
  • Emergency Medicine
  • Lung Injury
  • Weight Change