Strain threshold for ventilator-induced lung injury
© Santini et al. 2011
Published: 1 March 2011
Unphysiological lung strain (tidal volume/functional residual capacity, TV/FRC) may cause ventilator-induced lung injury (VILI) . Whether VILI develops proportionally to the applied strain or only above a critical threshold remains unknown.
In 20 healthy, mechanically ventilated pigs, FRC and lung weight were measured by computed tomography. Animals were then ventilated for up to 54 hours with a TV set to produce a predetermined strain. At the end, lung weight was measured with a balance. VILI was defined as final lung weight exceeding the initial one.
In animals with healthy lungs VILI only occurs when lung strain exceeds a critical threshold.
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