Volume 15 Supplement 1
Strain threshold for ventilator-induced lung injury
© Santini et al. 2011
Published: 1 March 2011
Unphysiological lung strain (tidal volume/functional residual capacity, TV/FRC) may cause ventilator-induced lung injury (VILI) . Whether VILI develops proportionally to the applied strain or only above a critical threshold remains unknown.
In 20 healthy, mechanically ventilated pigs, FRC and lung weight were measured by computed tomography. Animals were then ventilated for up to 54 hours with a TV set to produce a predetermined strain. At the end, lung weight was measured with a balance. VILI was defined as final lung weight exceeding the initial one.
In animals with healthy lungs VILI only occurs when lung strain exceeds a critical threshold.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.