Volume 15 Supplement 1

31st International Symposium on Intensive Care and Emergency Medicine

Open Access

NT-proBNP, troponin I and troponin T are elevated in ARDS patients without structural heart disease: a single initial reading of cardiac markers is not different from serial daily readings

  • Y Nassar1,
  • D Monsef1,
  • S Abdelshafy1 and
  • G Hamed1
Critical Care201115(Suppl 1):P131

https://doi.org/10.1186/cc9551

Published: 1 March 2011

Introduction

Myocardial injury and cardiac marker elevation may occur in ARDS patients without a structural heart disease, which might affect cardiac markers [1, 2].

Methods

The study was conducted in Cairo University Hospital between 1 June 2008 and 1 April 2009. The inclusion criterion was any adult patient diagnosed to have ARDS according to the criteria of the American-European Consensus Conference of 1994. Exclusion criteria were any pre-existing structural heart disease, pulmonary embolism, atrial fibrillation, renal insufficiency, age <18. Plasma levels of cardiac markers NT-proBNP, troponin I and troponin T were measured on day 0 and on day 2 and day 7 of ARDS diagnosis. All patients benefited from mechanical ventilation with a lung-protective ventilation strategy according to the NHBLI ARDS Network Treatment Protocol.

Results

The study comprised a total of 20 patients with mean age of 58.9 ± 20.69 years, 11 men versus nine women (P > 0.05). The ARDS aetiology was five (25%) patients due to sepsis, four (20%) due to pneumonia, three (15%) aspiration, three (15%) lung contusions due to road traffic accidents (RTA), two (10%) drug overdose, one (5%) burns, one (5%) pancreatitis, one (5%) drowning. NT-proBNP mean values were 8,903.3 ± 12,852.8 versus 6,083.6 ± 8,467.9 versus 9,914.8 ± 12,574.1 on day 0, day 2 and day 7, respectively (P > 0.05). Troponin I mean values were 3.0 ± 7.7 versus 2.2 ± 6.6 versus 1.5 ± 4.4 on day 0, day 2 and day 7, respectively (P > 0.05). Troponin T mean values were 0.3 ± 0.6 versus 0.6 ± 1.5 versus 0.5 ± 1.1 on day 0, day 2 and day 7, respectively (P > 0.05).

Conclusions

ARDS patients with structurally normal hearts show persistent elevated levels of cardiac markers NT-proBNP, troponin I and troponin T over the first week with no significant change between levels of day 0, day 2 and day 7. A single reading of cardiac markers on any day of the first week of ARDS may not be different from serial daily readings.

Authors’ Affiliations

(1)
Cairo University

References

  1. Phua J, et al.: B-type natriuretic peptide: issues for the intensivist and pulmonologist. Crit Care Med 2005, 33: 2094.View ArticlePubMedGoogle Scholar
  2. Leuchte , et al.: Clinical significance of brain natriuretic peptide in primary pulmonary hypertension. J Am Coll Cardiol 2004, 43: 764.View ArticlePubMedGoogle Scholar

Copyright

© Nassar et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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