- Poster presentation
- Open Access
Use of activated clotting time to monitor anticoagulation in patients receiving unfractionated heparin on renal replacement therapy
© Bidwai and Sundaram 2011
- Published: 1 March 2011
- Public Health
- Replacement Therapy
- Emergency Medicine
- Retrospective Analysis
The aim of our study was to determine the correlation between activated clotting time (ACT) and APTT values in patients receiving unfractionated heparin (UFH) for renal replacement therapy (RRT).
A retrospective analysis was made of case notes and laboratory data of 39 critically ill patients who were on UFH for RRT over a 1-year period. There were 183 paired APTT and ACT measurements done at the same time (29 patients). APTT was done at the laboratory and ACT was done at the bedside using an ACTALYKE monitor (Array Medical). Target APTT and ACT ranges for UFH during RRT were 45 to 55 seconds (control 27 to 32 seconds) and 250 to 270 seconds (control 180 to 220 seconds). Datasets were divided into three groups and the correlation coefficient (Pearson's) was calculated using SPSS software.
ACT versus APTT
Our data demonstrate that monitoring of anticoagulation with UFH using ACT cannot be recommended.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.