Skip to content

Advertisement

  • Poster presentation
  • Open Access

Any level of acute kidney injury may be associated with mortality in critically ill patients

  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Critical Care201115 (Suppl 1) :P103

https://doi.org/10.1186/cc9523

  • Published:

Keywords

  • Creatinine
  • Relative Risk
  • Serum Creatinine
  • Independent Risk Factor
  • Acute Kidney Injury

Introduction

Acute kidney injury (AKI) is a common condition in critically ill patients [1]. It is an independent risk factor for in-hospital mortality in this population [2]. The goal of this research is to classify critically ill patients within RIFLE criteria [3] and assess its impact on 30-day in-hospital mortality.

Methods

From September 2009 to July 2010, all patients admitted to two ICUs of Santa Casa Hospital were included in this study. Age, gender, SOFA and APACHE scores, origin, serum creatinine, whether they were clinical or surgical, and outcome were noted. Then patients were classified as 'no AKI', 'risk', 'injury', or 'failure' according to RIFLE criteria. The 30-day in-hospital mortality was also evaluated. A multivariate analysis model was created from potentially confusing variables that were statistically significant in an unvaried analysis. P < 0.05 was considered statistically significant.

Results

Two hundred and six patients were included. Most of them were women (54%), with an average age of 62 years. The mean APACHE score was 17 and the mean SOFA score was 5.8. The proportion, according to the RIFLE criteria, for patients at 'risk' was 17%, at 'injury' was 14%, 'failure' was 26% and 'no AKI' was 42%. The relative risk for 30-day in-hospital mortality for the group 'no AKI' was 0.5 (95% CI = 0.39 to 0.63; P < 0.001); for the 'risk' group was 1.7 (95% CI = 1.03 to 3.06; P = 0.037); for the 'injury' group was 1.66 (95% CI = 0.97 to 2.85; P = 0.062); and for the 'failure' group was 2.03 (95% CI = 1.22 to 3.37; P = 0.006).

Conclusions

AKI incidence, according to RIFLE classification, is high in critically ill patients. There is an association between AKI severity and mortality. It is noticeable that patients in the 'risk' group have increased mortality.

Authors’ Affiliations

(1)
Complexo Hospitalar Santa Casa, Porto Alegre, Brazil

References

  1. Uchino S, et al.: Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005, 294: 813-818. 10.1001/jama.294.7.813View ArticlePubMedGoogle Scholar
  2. Hoste EAJ, et al.: RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 2006, 10: R73. 10.1186/cc4915PubMed CentralView ArticlePubMedGoogle Scholar
  3. Bellomo R, et al.: Acute renal failure - definition, outcome measures, animal models, fluid therapy and inforation technology needs: the second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8: R204-R212. 10.1186/cc2872PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Rucks et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement