Volume 15 Supplement 1
Nicorandil versus nitroglycerin: a pilot study
© Singh et al. 2011
Published: 1 March 2011
Continuous exposure to nitrates is associated with tachyphylaxis. This study compares the effects and tolerance during intravenous treatment with nitroglycerin and nicorandil over a 48-hour period.
Twenty patients with congestive heart failure and pulmonary capillary wedge pressure (PCWP) ≥18 mmHg were randomly assigned to nitroglycerin or nicorandil intravenous infusions. Doses were titrated to obtain a reduction of PCWP of at least 30% at 6 hours and then maintained for 48 hours.
PCWP values before and after treatment
Intravenous nicorandil administration gives similar reductions in PCWP compared with nitroglycerin with significantly less haemodynamic tolerance over a 48-hour period compared with nitroglycerin. This might represent a clinical advantage of nicorandil in the short-term treatment of patients with congestive heart failure.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.