Volume 15 Supplement 1

31st International Symposium on Intensive Care and Emergency Medicine

Open Access

Dilution with three different solutions: plasmatic effects and quantity and quality of urinary output

  • T Langer1,
  • E Carlesso1,
  • A Protti1,
  • M Monti1,
  • L Zani1,
  • G Iapichino1,
  • B Comini1,
  • D Andreis1,
  • C Sparacino1,
  • D Dondossola2 and
  • L Gattinoni1
Critical Care201115(Suppl 1):P86

https://doi.org/10.1186/cc9506

Published: 1 March 2011

Introduction

Crystalloids have different electrolyte composition and therefore different strong ion differences (SIDinf). The aim of the study was to investigate the response of the kidney to plasmatic acid-base changes induced by dilution with three crystalloid solutions at different SID.

Methods

Six pigs (22 ± 4 kg) were anesthetized and mechanically ventilated. The respiratory rate was adjusted to maintain pCO2 constant. A urinary catheter was placed and connected to a urinary analyzer (Orvim, Paderno Dugnano, Italy) [1]. Pigs were randomly assigned to a sequence of dilutions (10% of body weight in 2 hours, followed by 4 hours of washout period) with the following three fluids: normal saline (NS), SID = 0, [Na] = 154, [Cl] = 154; lactated Ringer's (LR), SID = 29, [Na] = 132, [Cl] = 112; and polysaline RIII (RIII), SID = 55, [Na] = 140, [Cl] = 103. Blood gases and electrolytes as well as urinary pH (pHu), urinary electrolytes and urinary output (UO) were recorded at baseline and at the end of each dilution. Plasmatic SID was defined as [Na] + [K] + 2[Ca] - [Cl] - [Lac]. Variations (d) were defined as baseline - 2-hour value.

Results

Plasmatic changes are consistent with previous in vitro studies [2]. dSID was mainly due to d[Cl]: 9.0 ± 1.7 for NS, no change for LR, -1.5 ± 1.6 for RIII. Of note, while no difference was yet observed for urinary electrolytes and UO, pHu significantly differed between the three solutions. See Table 1.

Table 1

 

NS

LR

RIII

dpHa

-0.08 ± 0.02

-0.00 ± 0.03*

0.04 ± 0.03*#

dSID (mEq/l)

-4.56 ± 1.36

0.21 ± 1.41*

3.56 ± 1.95*#

dpHu

-0.16 ± 0.47

0.23 ± 0.44

1.00 ± 0.75*#

UO (ml)

639 ± 235

768 ± 172

896 ± 293

Data presented as mean ± standard deviation. *P < 0.05 vs. NS. #P < 0.05 vs. LR. One-way ANOVA RM.

Conclusions

The quality of infused fluids affects greatly the acid-base and electrolyte equilibrium of plasma. This in turn alters the quality of urine (pHu).

Authors’ Affiliations

(1)
Università degli Studi di Milano
(2)
Centro Ricerche Chirurgiche Precliniche, Università degli Studi

References

  1. Caironi P: Minerva Anestesiol. 2010, 76: 316-324.PubMedGoogle Scholar
  2. Carlesso E: Intensive Care Med. 2010Google Scholar

Copyright

© Langer et al. 2011

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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