- Poster presentation
- Open Access
Carotid blood flow is correlated with cardiac output but not with arterial blood pressure in porcine fecal peritonitis
© Correa et al. 2011
- Published: 1 March 2011
- Cardiac Output
- Cerebral Blood Flow
- Cardiac Index
- Arterial Blood Pressure
- Systemic Blood
Cerebral blood flow may be impaired in sepsis . The objective of this study is to evaluate whether and how carotid blood flow (CBF) depends on cardiac output and mean arterial blood pressure in abdominal sepsis.
Thirty-two anesthetized pigs (weight: 40.3 ± 3.7 kg (mean ± SD)) were randomly assigned (n = 8 per group) to a nonseptic control group (CG) or one of three groups in which resuscitation was initiated 6, 12 or 24 hours after induction of fecal peritonitis (instillation of 2 g/kg autologous feces). In the treatment groups, resuscitation was performed for 48 hours according to the Surviving Sepsis Campaign. The CG was observed for 72 hours. CBF (carotid artery; ultrasound Doppler flow), cardiac output (intermittent thermodilution) and arterial blood pressure (MAP) were measured at 6-hour intervals. Pearson correlation were performed between CBF index (CBFI) and cardiac index (CI) and MAP, respectively, both in individual animals and in pooled septic and control groups.
Under the experimental conditions, increasing systemic blood flow but not blood pressure has the potential to improve CBF.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.