Skip to main content

Carotid blood flow is correlated with cardiac output but not with arterial blood pressure in porcine fecal peritonitis

Introduction

Cerebral blood flow may be impaired in sepsis [1]. The objective of this study is to evaluate whether and how carotid blood flow (CBF) depends on cardiac output and mean arterial blood pressure in abdominal sepsis.

Methods

Thirty-two anesthetized pigs (weight: 40.3 ± 3.7 kg (mean ± SD)) were randomly assigned (n = 8 per group) to a nonseptic control group (CG) or one of three groups in which resuscitation was initiated 6, 12 or 24 hours after induction of fecal peritonitis (instillation of 2 g/kg autologous feces). In the treatment groups, resuscitation was performed for 48 hours according to the Surviving Sepsis Campaign. The CG was observed for 72 hours. CBF (carotid artery; ultrasound Doppler flow), cardiac output (intermittent thermodilution) and arterial blood pressure (MAP) were measured at 6-hour intervals. Pearson correlation were performed between CBF index (CBFI) and cardiac index (CI) and MAP, respectively, both in individual animals and in pooled septic and control groups.

Results

Altogether 227 measurements were obtained during sepsis and 128 in controls. In septic animals, CBFI and CI (r = 0.53, P < 0.001; Figure 1) but not CBFI and MAP correlated (Figure 2). In controls, CBFI and MAP correlated weakly and inversely (r = -0.246, P = 0.005; data not shown).

Figure 1
figure1

Correlation between CBFI and CI.

Figure 2
figure2

Correlation between CBFI and MAP.

Conclusions

Under the experimental conditions, increasing systemic blood flow but not blood pressure has the potential to improve CBF.

References

  1. 1.

    Taccone FS: Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care 2010, 14: R140.

    PubMed Central  Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to T Correa.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Correa, T., Blaser, A.R., Takala, J. et al. Carotid blood flow is correlated with cardiac output but not with arterial blood pressure in porcine fecal peritonitis. Crit Care 15, P70 (2011). https://doi.org/10.1186/cc9490

Download citation

Keywords

  • Cardiac Output
  • Cerebral Blood Flow
  • Cardiac Index
  • Arterial Blood Pressure
  • Systemic Blood