Skip to main content
  • Poster presentation
  • Open access
  • Published:

Prediction of fluid responsiveness with the LiDCO system


Variation in stroke volume (SV) or related parameters induced by passive leg raising (PLR) measured by several non-invasive methods has been demonstrated to reliably predict fluid responsiveness [1]. The aim of this study was to assess whether variation in SV measured by LiDCO can predict fluid responsiveness in shock states.


ICU patients with signs of shock were enrolled. History, clinical information and echocardiogram were obtained. After calibration, hemodynamic evaluation was performed by LiDCO in four subsequent steps: T1 in semi-recumbent position; T2 during PLR; T3 in baseline position; T4 after infusion of 500 ml NaCl 0.9% in 15 minutes. On each step, the heart rate (HR), mean arterial pressure (MAP), absolute and indexed cardiac output and stroke volume (CO/CI, SV/SVI) were measured by LiDCO and the aortic velocity time integral (VTI) by transthoracic echocardiography. Patients whose SVI increased at least 10% after volume load were classified as responders. The ability to predict responder state was assessed for four potential fluid responsiveness indices: variation in SVI, CO, CI and VTI induced by PLR (ΔSVI-PLR, ΔCO-PLR, ΔCI-PLR, ΔVTI-PLR) by means of three statistical methods: comparison (Mann-Whitney) between the mean value of index in responders and nonresponders, correlation (Spearman) between the baseline value of index and increase in SVI after fluids, and the receiver operator characteristic (ROC) curve.


Fifteen determinations were collected in 13 patients in septic, cardiogenic and hypovolemic shock (males 9/13, age 73.2 ± 5.8, ejection fraction 54% ± 8). Ten patients had spontaneous breathing activity, five had arrhythmias, 11 were under inotropes. The responder rate was 46.7%. Among the studied indices, only ΔSVI-PLR was significantly different in responders and nonresponders (26.9 vs. 1.9, P < 0.001). Three indices, ΔSVI-PLR, ΔCO-PLR and ΔCI-PLR, were significantly correlated with increase in SVI after fluids (rho = 0.854 (P < 0.001), 0.727 (P = 0.002), 0.710 (P = 0.003)). ΔSVI-PLR correctly predicted responders state in all cases with a threshold of 9.1%, (sensitivity 100%, specificity 100%, area under the ROC curve (AUC) 1.00 (P < 0.001 95% CI = 1.00 to 1.00)). The other indices had values of AUC not significantly different from 0.5.


The ΔSVI-PLR, measured with the LiDCO system, is a very reliable predictor of fluid responsiveness in a population of ICU patients in shock, including patients with spontaneous breathing activity and arrhythmias.


  1. Cavallaro , et al.: Intensive Care Med. 2010, 36: 1475-1483.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Cite this article

De Santis, P., Marano, C., Cavallaro, F. et al. Prediction of fluid responsiveness with the LiDCO system. Crit Care 15 (Suppl 1), P64 (2011).

Download citation

  • Published:

  • DOI: