- Poster presentation
- Open Access
LiDCOrapid and PiCCOplus preload response parameter validation study
© Brass et al. 2011
- Published: 1 March 2011
- Fluid Responsiveness
- Pulse Pressure Variation
- Stroke Volume Variation
- Fluid Challenge
- Pressure Infusion
This study compares the ability of two arterial waveform monitors, the calibrated PiCCOplus and the nomogram scaled LiDCOrapid, to detect fluid responsiveness using the functional hemodynamic parameters stroke volume variation (SVV) and pulse pressure variation (PPV) in a surgical ICU population (ventilated, closed chest). The passive leg raising test (PLRT) is an alternative reversible test that can be carried out before administering volume.
We recruited 20 patients who had undergone major abdominal or neurosurgery and 10 patients in the SICU with progressive circulatory instability. The femoral artery was cannulated to obtain the arterial blood pressure waveform. Simultaneous measurements were made at four time points, M1 to M4: (M1) baseline, (M2) after PLRT, (M3) baseline (M4), after 500 ml Tetraspan® 6% over 10 minutes via pressure infusion. The PiCCO was calibrated via transpulmonary thermodilution at each time point. A change in SV >10% was considered as volume responsive.
This study has demonstrated that SVV, PPV, and PLRT to a lesser extent, are effective for predicting volume response and can be used perioperatively for fluid management as part of goal-directed therapy. The sensitivity and specificity of the SVVL and PPVL were both greater than the SVVP. This is probably due to the difference in each algorithm's ability to identify responders to the fluid challenge.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.