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- Open Access
Positive central-mixed venous oxygen saturation gradients: high oxygen saturation in the inferior vena cava confirms high splanchnic oxygen extraction
© Blaser et al. 2011
- Published: 1 March 2011
- Inferior Vena Cava
- Inferior Vena
- Superior Vena
- Oxygen Extraction
Central venous oxygen saturation (ScvO2) is increasingly used as a surrogate for mixed venous oxygen saturation (SvO2). On average, there is a positive gradient between ScvO2 and SvO2 that has been explained by the low inferior vena cava saturation (SivcO2). We aimed to clarify the dynamics and associations between different venous saturations in an experimental setting of porcine peritonitis.
Thirty-two anaesthetized pigs (40.3 ± 3.8 kg (mean ± SD)) were randomly assigned (n = 8 per group) to a nonseptic control group or one of three septic groups in which the pigs were observed for 6, 12 or 24 hours. Thereafter, resuscitation was performed for 48 hours. The pulmonary artery, superior vena cava and inferior vena cava (IVC) were catheterized. The catheter for IVC measurements was placed 5 cm below the diaphragm. SvO2, ScvO2 and SivcO2 were measured at 12-hour intervals starting at study baseline. Differences between saturations at different time points were tested with a t test for paired measurements.
In most of the measurements, both ScvO2 and SivcO2 were higher than SvO2. Our results suggest a high oxygen extraction of splanchnic organs as the reason for positive ScvO2-SvO2 gradients.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.