- Poster presentation
- Open Access
Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery
© Klein et al. 2011
- Published: 1 March 2011
- Observational Study
- Primary Outcome
- Emergency Medicine
- Secondary Outcome
- Cardiopulmonary Bypass
The purpose of this study was to examine the prevalence of endotoxemia-supported aortocoronary bypass grafting surgery (ACB), using the endotoxin activity assay (EAA), and to explore the association between endotoxemia and postoperative infection.
The study was a single-center prospective observational study measuring EAA during the perioperative period for elective ACB. Blood samples were drawn at induction of anesthesia (T1), immediately prior to release of the aortic cross-clamp (T2), and on the first postoperative morning (T3). The primary outcome was the prevalence of endotoxemia. The secondary outcome was rate of postoperative infection. An EAA of <0.40 was interpreted as low, 0.41 to 0.59 as intermediate, and >0.60 as high.
High levels of endotoxin occurred less frequently during ACB than previously documented. However, endotoxemia is associated with a significantly increased risk of the development of postoperative infection - a complication associated with an over doubling of risk of death. Measuring endotoxin levels may provide a mechanism to identify and target a high-risk population.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.