Table 1 Systemic hemodynamic measurements and pulmonary hemodynamic measurements

Weight (kg)

Control

30.4 ± 0.69

LPS + Vehicle

31.0 ± 0.58

LPS + Netrin i.v.

30.2 ± 0.20

LPS + Netrin inh.

29.8 ± 0.49

CI (ml min^-1 kg^-1)

Control

166 ± 3.0

167 ± 5.1

156 ± 10.4

LPS + Vehicle

170 ± 5.1

136 ± 10.5

122 ± 7.3*

LPS + Netrin i.v.

163 ± 9.2

128 ± 11.9

114 ± 9.4*

LPS + Netrin inh

160 ± 3.4

130 ± 11.9

118 ± 8.4*

MAP (mmHg)

Control

68 ± 3.7

77 ± 4.9

84 ± 3.7

LPS + Vehicle

75 ± 6.0

89 ± 3.2

119 ± 6.4*

LPS + Netrin i.v.

78 ± 6.5

97 ± 6.9*

124 ± 7.0*

LPS + Netrin inh.

86 ± 6.7

93 ± 2.7

118 ± 4.5*

MPAP (mmHg)

Control

16 ± 1.4

17 ± 1.4

17 ± 1.8

LPS + Vehicle

17 ± 0.7

31 ± 1.8*

31 ± 2.0*

LPS + Netrin i.v.

18 ± 0.8

31 ± 2.0*

34 ± 2.3*

LPS + Netrin inh

16 ± 0.5

28 ± 2.5*

31 ± 3.3*

SVR (dyne*s*cm5 kg^-1)

Control

34 ± 1.6

39 ± 3.7

47 ± 5.6

LPS + Vehicle

36 ± 3.6

54 ± 3.8

80 ± 8.1*

LPS + Netrin i.v.

41 ± 4.6

66 ± 7.8*

95 ± 11.4*

LPS + Netrin inh

47 ± 4.2

64 ± 6.2*

88 ± 7.0*

PVR (dyne*s*cm5 kg^-1)

Control

6.5 ± 0.6

6.7 ± 0.4

7.2 ± 0.7

LPS + Vehicle

6.6 ± 0.4

16.6 ± 2.3*

16.9 ± 1.4*

LPS + Netrin i.v.

7.1 ± 0.5

16.6 ± 2.4*

20.6 ± 3.0*

LPS + Netrin inh.

6.8 ± 0.4

15.5 ± 2.8*

18.9 ± 2.1*

PCWP (mmHg)

Control

3.9 ± 0.4

3.9 ± 0.5

4.0 ± 0.5

LPS + Vehicle

3.2 ± 0.6

5.1 ± 0.9

6.6 ± 1.9*

LPS + Netrin i.v.

4.4 ± 0.3

7.0 ± 0.5*

8.0 ± 0.5*

LPS + Netrin inh

4.4 ± 0.5

6.8 ± 0.5*

7.6 ± 0.5*

ITBVI (ml kg^-1)

Control

33.3 ± 1.5

33.0 ± 0.7

30.8 ± 1.6

LPS + Vehicle

31.9 ± 1.8

28.0 ± 1.3

32.0 ± 3.0

LPS + Netrin i.v.

34.4 ± 3.1

31.9 ± 2.0

35.5 ± 2.1

LPS + Netrin inh.

32.1 ± 1.3

29.0 ± 0.8

33.0 ± 0.6

EVLWI (ml kg^-1)

Control

5.5 ± 0.4

6.0 ± 0.6

6.5 ± 0.5

LPS + Vehicle

5.7 ± 0.7

9.1 ± 2.1

9.7 ± 1.3*

LPS + Netrin i.v.

5.1 ± 0.7

7.5 ± 0.4

11.9 ± 1.4*

LPS + Netrin inh.

4.8 ± 0.4

6.3 ± 0.7

8.1 ± 1.3*