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Figure 1 | Critical Care

Figure 1

From: The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury

Figure 1

Experimental protocol. Control animals received mechanical ventilation only. Acute lung injury (ALI) was induced through lipoploysaccharide (LPS) infusion (50 μg/kg over 2 h), and subsequently animals were treated with either vehicle (50 ml of NaCl 0.9% + 1 mg of bovine serum albumin), netrin-1 i.v. (1 mg i.v. in 50 ml of NaCl 0.9%) or netrin-1 inh. (1 mg in 50 ml of NaCl 0.9%) for 2 hours. Following this, the observation period was 6 hours until the end of the experimental protocol. Hemodynamic measurements, serum levels of cytokines and bronchoalveolar lavage (BAL) were determined as indicated.

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Critical Care

ISSN: 1364-8535