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Impact of delayed antimicrobial therapy in septic ITU patients
Critical Care volume 14, Article number: P20 (2010)
There is evidence that early delivery of antibiotics following the recognition of severe sepsis leads to decreased morbidity and indeed mortality. It is estimated that 36,800 people die annually in the UK as a result of severe sepsis, claiming more lives than bowel and breast cancer combined . Patients admitted to ICUs with severe sepsis have a 39.8% risk of death , and for each hour delay in antibiotic administration, a 7.6% increase in mortality . The Surviving Sepsis Campaign 2008 recommends that appropriate antimicrobial therapy be administered within 1 hour following recognition of severe sepsis .
We conducted a prospective audit of consecutive patients with severe sepsis admitted to an ITU between February and June 2010. The patients were identified as those who fulfilled two or more components of the systemic inflammatory response syndrome (SIRS) criteria, and had evidence of organ dysfunction requiring critical care. Compliance to the Surviving Sepsis Campaign's antibiotic care bundle was audited. The relationship between time of antibiotic administration and mortality was also determined.
During the study period, 33 patients out of 187 admissions met the inclusion criteria. The population demographics are illustrated in Table 1. The mean time from fulfilling SIRS criteria to delivery of antibiotics was 4.32 hours. Only eight (25%) of the patients received antibiotics within the hour, with the mortality rate for this group being 25%. Those patients who received antibiotics after 4 hours had a lower mortality rate than the group that received antibiotics after 12 hours (67% vs. 80%). See Figure 1.
Our results support published evidence that a delay in antibiotic delivery greater than 1 hour is associated with increased mortality in patients treated in the ITU. As a result of this study we have developed a standardized sepsis protocol to integrate into the AE triage pro forma, as well as a pathway to help instigate treatment earlier to those patients identified as septic on the wards. Recruitment period has not concluded. More data analysis will be presented later.
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Dellinger RP, Levy MM, Carlet JM, et al.: International guidelines for management of severe sepsis and septic shock. Crit Care Med 2008, 36: 296-327. 10.1097/01.CCM.0000298158.12101.41
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Frost, R., Newsham, H., Parmar, S. et al. Impact of delayed antimicrobial therapy in septic ITU patients. Crit Care 14, P20 (2010). https://doi.org/10.1186/cc9123
- Breast Cancer
- Severe Sepsis
- Critical Care
- Organ Dysfunction
- Systemic Inflammatory Response Syndrome