Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study

Table 3 Systemic hemodynamic values and blood pressure variation before and after volume challenges

		Volume challenges during endotoxemia		Volume challenges in controls
		Before	After	Before	After
HR	All	114 ± 15	113 ± 13	113 ± 16	114 ± 16
(beats/min)	Responders	115 ± 16	110 ± 14	111 ± 17	110 ± 16
	Nonresponders	113 ± 12	115 ± 13	116 ± 15	122 ± 13
MAP	All	90 ± 30	98 ± 26*	90 ± 30	100 ± 23*
(mmHg)	Responders	86 ± 31	99 ± 25	81 ± 30^†	95 ± 23
	Nonresponders	96 ± 28	96 ± 28	108 ± 20	110 ± 19
CO	All	4.3 ± 1.4	4.8 ± 1.3*	5.8 ± 2.7	6.8 ± 2.6*
(l/min)	Responders	3.7 ± 1.3^†	4.6 ± 1.2	4.6 ± 2.4^†	5.9 ± 2.6
	Nonresponders	4.9 ± 1.3	5.0 ± 1.3	8.2 ± 1.5	8.5 ± 1.3
SV	All	38 ± 14	43 ± 12*	52 ± 24	59 ± 21*
(ml)	Responders	33 ± 13^†	42 ± 12	42 ± 22^†	54 ± 22
	Nonresponders	44 ± 12	44 ± 12	71 ± 14	71 ± 13
CVP	All	12 ± 4	13 ± 4*	7 ± 3	8 ± 3*
(mmHg)	Responders	10 ± 4^‡	12 ± 4	6 ± 3^†	7 ± 3
	Nonresponders	13 ± 4	14 ± 4	10 ± 3	11 ± 2
PAOP	All	11 ± 4	12 ± 4*	9 ± 4	10 ± 4*
(mmHg)	Responders	11 ± 3	12 ± 4	7 ± 3^†	9 ± 3
	Nonresponders	12 ± 4	13 ± 5	12 ± 3	13 ± 3
PPV	All	13 ± 7	12 ± 6	11 ± 8	9 ± 4*
(%)	Responders	14 ± 7	12 ± 5	14 ± 8^†	9 ± 5
	Nonresponders	12 ± 7	11 ± 6	7 ± 3	8 ± 4

Systemic hemodynamic values and blood pressure variation before and after volume challenges during endotoxemia (before and after bleeding) and in controls (after bleeding). Data presented as mean ± standard deviation. HR, heart rate; MAP, mean arterial blood pressure; CO, cardiac output; SV, stroke volume; CVP, central venous pressure; PAOP, pulmonary artery occlusion pressure; PPV, pulse pressure variation. *P < 0.005, compared with before. ^†P ≤ 0.001, compared with nonresponders; ^‡P < 0.05, compared with nonresponders.

ISSN: 1364-8535