Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study

Table 2 Prediction of increase in stroke volume based on receiver operating characteristic curves

	Fluid challenges (n)	Responders, n(%)	Nonresponders, n(%)	AUC (95% CI)	P value	Best PPV threshold (%)^a
All fluid challenges in endotoxemia	68	37 (54)	31 (46)	0.642 (0.505 to 0.778)	0.045	12
Volume expansion before bleeding	22	15 (68)	7 (32)	0.610 (0.365 to 0.854)	0.418	10
After bleeding during retransfusion and volume expansion	46	22 (48)	24 (52)	0.699 (0.543 to 0.854)	0.021	9
All fluid challenges in endotoxemia with CVP increase	60	34 (57)	26 (43)	0.633 (0.485 to 0.780)	0.080	9
Volume expansion before bleeding	20	14 (70)	6 (30)	0.595 (0.335 to 0.855)	0.509	9
After bleeding during retransfusion and volume expansion	40	20 (50)	20 (50)	0.698 (0.528 to 0.867)	0.033	9
All fluid challenges in controls after bleeding	51	34 (67)	17 (33)	0.79 (0.664 to 0.915)	0.001	9^b
All fluid challenges in controls after bleeding with CVP increase	39	28 (72)	11 (28)	0.724 (0.556 to 0.892)	0.031	11

AUC, area under the receiver operating characteristic curve; CVP, central venous pressure; CI, confidence interval; PPV, pulse pressure variation. ^aBest PPV thresholds calculated despite P values that are not significant. ^bThreshold for controls is the mean value between two with identical sum of sensitivity and specificity (8% and 10%).

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