Non-invasive ventilation in acute respiratory failure related to 2009 pandemic Influenza A/H1N1 virus infection
Critical Care volume 14, Article number: 408 (2010)
Non-invasive ventilation (NIV) is considered first-line intervention for different causes of acute respiratory failure . However, Rello and colleagues  show high rates of NIV failure in pandemic Influenza A/H1N1 virus infection (PH1N1).
We describe a patient with PH1N1 in whom NIV was effective. A 53-year-old male was admitted in November 2009 with cough, dyspnea, and hemoptysis. His temperature was 38.9°C, he was tachypneic, with diffuse rhonchi and bilateral crackles, and oxygen saturation was 96% (4 L/min oxygen). Arterial partial pressure of oxygen (PaO2) and arterial partial pressure of carbon dioxide (PaCO2) were 76 and 23 mm Hg, respectively. Creatine kinase (2,278 U/L) and brain natriuretic peptide (3,544 pg/mL) were increased. Acute myocardial infarction was excluded. Chest x-ray showed bilateral interstitial infiltrates and cardiomegaly. Echocardiogram showed severe left ventricular systolic dysfunction. PH1N1 pneumonia was suspected, and oseltamivir was administered in association with antibiotics and diuretics. On day 2, a nasopharyngeal swab was positive for PH1N1. The patient was subsequently transferred to a negative-pressure ward. He was still tachypneic, with basal crackles and a PaO2/fraction of inspired oxygen (FiO2) ratio of 246. NIV (BiPAP Vision; Philips Respironics, Murrysville, PA, USA) through an oro-nasal mask inbilevel positive airway pressure mode (inspiratory positive airway pressure [IPAP] = 16 cm H2O, expiratory positive airway pressure [EPAP] = 8 cm H2O) was started. Due to patient preference, the mode was changed to continuous positive airway pressure (CPAP) at 10 cm H2O and an FiO2 of 25%. After 1 hour, PaO2/FiO2 increased to 364, and CPAP was stopped after 12 hours.
Recently, Djibré and colleagues  demonstrated the effectiveness of NIV in acute respiratory distress syndrome related to PH1N1 pneumonia. Our case further supports its role in a hypoxemic patient with cardiogenic pulmonary edema and PH1N1 pneumonitis.
Alejandro Rodríguez, Thiago Lisboa, Jordi Rello and H1N1 SEMICYUC Working Group
We appreciate the interest from Winck and Marinho in our article and their insightful observations regarding non-invasive ventilation (NIV) in severe influenza A (H1N1)v. The use of NIV in hypoxemic respiratory failure is controversial, and the etiology of hypoxemia appears to be an important determinant of its success. A meta-analysis  suggests that non-invasive positive-pressure ventilation does not decrease the need for intubation, so there is not enough evidence to support its use in acute respiratory distress syndrome. Our experience  is consistent with other reports [5, 6]; 25% to 30% of patients were non-invasively ventilated on admission, but 70% to 85% of these patients required subsequent intubation and invasive ventilation. There are only a few patients with H1N1-related respiratory failure who seem to benefit from NIV alone, so it should be reserved for patients with milder disease. Guidelines endorsed by the European Respiratory Society and European Society of Intensive Care Medicine  conclude that, as a general rule, NIV not be recommended as an alternative to invasive ventilation in patients affected by H1N1. In spite of this, selected patients with hypoxemia and additional cardiac compromise (severe left ventricular systolic dysfunction) or presenting with exacerbation of chronic obstructive pulmonary disease might benefit from this alternative therapy as it has been reported.
continuous positive airway pressure
fraction of inspired oxygen
arterial partial pressure of oxygen
pandemic Influenza A/H1N1 virus infection.
Brochard L: Noninvasive ventilation for acute respiratory failure. JAMA 2002, 288: 932-935. 10.1001/jama.288.8.932
Rello J, Rodríguez A, Ibañez P, Socias L, Cebrian J, Marques A, Guerrero J, Ruiz-Santana S, Marquez E, Del Nogal-Saez F, Alvarez-Lerma F, Martínez S, Ferrer M, Avellanas M, Granada R, Maraví-Poma E, Albert P, Sierra R, Vidaur L, Ortiz P, Prieto del Portillo I, Galván B, León-Gil C, H1N1 SEMICYUC Working Group: Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain. Crit Care 2009, 13: R148. 10.1186/cc8044
Djibré M, Berkane N, Salengro A, Ferrand E, Denis M, Chalumeau-Lemoine L, Parrot A, Mayaud C, Fartoukh M: Non-invasive management of acute respiratory distress syndrome related to Influenza A (H1N1) virus pneumonia in a pregnant woman. Intensive Care Med 2010, 36: 373-374. 10.1007/s00134-009-1684-0
Agarwal R, Reddy C, Aggarrwal AN, Gupta D: Is there a role for noninvasive ventilation in acute respiratory distress syndrome? A meta-analysis. Respir Med 2006, 100: 2235-2238. 10.1016/j.rmed.2006.03.018
Ramsey CD, Funk D, Miller DF III, Kumar A: Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus. Crit Care Med 2010.,3(suppl):
Rodriguez A, Lisboa T, Rello J: Pandemic influenza A (H1N1)v in the intensive care unit: what have we learned? Arch Bronchoneumol 2010,46(suppl 2):24-31.
Conti G, Larrsson A, Nava S, Navalesi P: On the role of non-invasive (NIV) to treat patients during the H1N1 influenza pandemic.[http://dev.ersnet.org/uploads/Document/63/WEB_CHEMIN_5410_1258624143.pdf]
Written consent for publication was obtained from the patient.
The authors declare that they have no competing interests.
About this article
Cite this article
Winck, J.C., Marinho, A. Non-invasive ventilation in acute respiratory failure related to 2009 pandemic Influenza A/H1N1 virus infection. Crit Care 14, 408 (2010). https://doi.org/10.1186/cc8896
- Chronic Obstructive Pulmonary Disease
- Continuous Positive Airway Pressure
- Acute Respiratory Distress Syndrome
- Brain Natriuretic Peptide
- Acute Respiratory Failure