From: Bench-to-bedside review: The role of β-lactamases in antibiotic-resistant Gram-negative infections
β-Lactams to which resistance is conferred | ||||
---|---|---|---|---|
Functional groupa | Molecular classb | Common name | Primaryc | Secondaryd |
1 | C | Cephalosporinase | Penicillins, cephalosporins | Carbapenems, monobactams |
2b | A | Penicillinase | Penicillins, early cephalosporins | β-lactamase inhibitor combinations |
2be | A | Extended-spectrum β-lactamase | Penicillins, cephalosporins, monobactams, β-lactamase inhibitor combinations | None |
2d | D | Cloxacillinase | Penicillins, including oxacillin and cloxacillin | None |
2df | D | Carbapenemase | Carbapenems and other β-lactams | None |
2f | A | Carbapenemase | All current β-lactams | None |
3 | B | Metallo-β-lactamase | All β-lactams except monobactams | None |