Brain metabolism is significantly impaired at blood glucose below 6 mM and brain glucose below 1 mM in patients with severe traumatic brain injury

Table 1 Changes in ICP, CPP, ptiO₂, SjvO₂, and insulin requirements for different arterial blood glucose clusters

Blood glucose	<5 mM	5-5.9 mM	6-6.9 mM	7-7.9 mM	8-8.9 mM	>9 mM
n (Σ = 3102)	125	744	1195	736	221	81
	4.0%	23.9%	38.5%	23.7%	7.1%	2.6%
ICP (mmHg)	14, 0-50	14, 0-59	14, 1-74	15, 0-92	15, 0-53	15, 1-88
CPP (mmHg)	76, 47-98	78, 51-115	79, 32-111	79, 30-146	78, 60-120	77, 27-109
ptiO₂ (mmHg)	31, 15-50	31, 17-81	32, 13-80	31, 11-79	28, 11-77	31, 16-54
SjvO₂ (%)	72, 60-93	67, 59-90	71, 59-87	70, 47-93	81, 65-92	79, 57-95
Insulin (units/h)	0, 0-2.5	0, 0-2.5	0, 0-3.3	0.2, 0-3.3	0.8, 0-3.3	1, 0-2.5

CPP = cerebral perfusion pressure; ICP = intracranial pressure; ptiO2 = tissue oxygen partial pressure; SjvO2 = jugularvenous oxygen saturation.
Results are shown as median, range (min to max)

ISSN: 1364-8535