- Poster presentation
- Open Access
Dexamethasone treatment during cardiac surgery and postoperative lactate levels
© BioMed Central Ltd. 2010
- Published: 1 March 2010
- Cardiopulmonary Bypass
- Mitochondrial Membrane Potential
Glucocorticoids are known to have an anti-insulin action on glucose metabolism, leading to increased lactate production . Alternatively, glucocorticoid-induced apoptosis is a well-recognized phenomenon initiated by mitochondrial dysfunction . Increased lactate production follows loss of mitochondrial membrane potential during apoptosis. Both mechanisms may lead to clinically relevant hyperlactatemia following glucocorticoid administration during cardiac surgery requiring cardiopulmonary bypass.
All adult patients undergoing cardiac surgery and cardiopulmonary bypass from 5 October through 21 November 2005 in a large academic teaching hospital in Rotterdam, the Netherlands were included in this study. Dexamethasone (60 to 80 mg) was given perioperatively at the discretion of the anesthetist. Lactate levels were measured within 1 hour postoperatively. The association between dexamethasone treatment, serum lactate levels and possible confounders was evaluated using ANOVA and linear regression.
Administration of dexamethasone during cardiac surgery requiring cardiopulmonary bypass is associated with a significant hyperlactatemia.