On day 3, animals (n = 10) had hyperbilirubinemia (5.2 ± 0.3 mg/dl; mean ± SEM) and hyperammonemia (264 ± 38 μg/dl). Endotoxemia in control animals resulted in severe multisystem organ failure and death (after 6.4 ± 0.3 hours) although they received only one-third of the total endotoxin dose on average. HW improved cardiovascular (Figure 1), cerebral, respiratory and renal parameters and eliminated surrogate parameters as bilirubin (2.8 ± 0.5 vs 5.2 ± 0.3 mg/dl P < 0.05) and ammonia (189 ± 38 vs 1,108 ± 455 μg/dl, P < 0.05). All animals in the HW group survived the 10-hour observation period (P < 0.05). We did not notice any adverse effects during treatment.