Multidrug sedation as a risk factor for deep vein thrombosis in the intensive care unit
© BioMed Central Ltd. 2010
Published: 1 March 2010
Critically ill patients are at high risk for deep vein thrombosis (DVT). Among ICU DVT risk factors, the role of muscle relaxant (MR) has been clearly shown  but the possible influence of sedative medications (SM) is still under debate. This study was aimed at investigating whether the use of different SM may affect DVT incidence in ICU patients.
Over the period of study, 380 patients were enrolled. Lower limb DVT was diagnosed in 23 of 380 patients, with a DVT incidence of 6.05%. MRs were administered in 121 patients and they were associated with DVT incidence (P < 0.001). Statistical analysis results performed on 259 patients are shown in Figure 1: none of the considered SM resulted to be associated with DVT incidence, nor sedation as a whole or the number of SM administered.
Our study confirms prior findings  on the MR role as a DVT risk factor. Nevertheless, SM administration in patients not treated with MR is not associated with increased DVT risk.
- J Thromb Haemost. 2009, in press. [DOI: 10.1111/j.1538-7836.2009.03664.x]Google Scholar