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Effects of severe hemorrhage on pulmonary mechanics in ventilated pigs with ARDS
Critical Care volume 14, Article number: P181 (2010)
The effects of hemorrhagic shock on respiratory system mechanics have rarely been investigated and published data are controversial. Pulmonary compliance depends in part on intrapulmonary blood and interstitial fluid volume. When compliance is severely reduced, small modification of these components may have important effects. The present analysis explored the effect of hemorrhagic shock on respiratory system mechanics and oxygenation parameters in a model of pigs with ARDS.
We evaluated the dynamic respiratory system compliance (Crs = VT/(inspiratory airways pressure - PEEP)) of 14 domestic pigs. Animals were mechanically ventilated: tidal volume (VT) set at 10 ml/kg; respiratory rate at 15 bpm; PEEP at 0 cmH2O. Animals were separated into a control group (n = 9) and an ARDS group (n = 5). ARDS was induced by lung lavage with NaCl 0.9%. During hemorrhage 40% of the total blood volume was removed. The blood was then infused during the re-transfusion phase.
In the control group, Crs (ml/cmH2O) did not change during hemorrhage or re-transfusion (Figure 1). In the ARDS group, Crs decreased with lung lavage (31.2 ± 5.7 (baseline) to 16.4 ± 3.0; *P < 0.01). After hemorrhage Crs increased (21.5 ± 2.9; **P < 0.001 compared with lavage) and then decreased again after re-transfusion (18.7 ± 2.7; ***P < 0.05). In the same group PaO2/FiO2 (mmHg) decreased after ARDS (469 ± 50 (baseline) to 105 ± 38; P < 0.001), increased during hemorrhage (218 ± 105; P < 0.05) and did not change after re-transfusion (207 ± 125; P = 0.82). The shunt fraction (%) decreased during hemorrhage in the ARDS group (26.2 ± 14.9 (lavage) to 6.4 ± 6.6; P < 0.05) but did not change significantly after re-transfusion (13.9 ± 17.0; P = 0.3).
Acute reduction of blood volume is associated with an increase of respiratory system compliance and oxygenation parameters. Reduction of intrapulmonary blood and interstitial fluid volume or thoracic cage compliance could be responsible for this effect.
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Siegenthaler, N., Giraud, R., Morel, D. et al. Effects of severe hemorrhage on pulmonary mechanics in ventilated pigs with ARDS. Crit Care 14, P181 (2010). https://doi.org/10.1186/cc8413
- Blood Volume
- Respiratory System
- Hemorrhagic Shock
- Lung Lavage
- Total Blood Volume