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  • Poster presentation
  • Open Access

Delayed increase in inflammation and thenar VO2 in marathon runners

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 2,
  • 1,
  • 1,
  • 1 and
  • 1
Critical Care201014 (Suppl 1) :P149

https://doi.org/10.1186/cc8381

  • Published:

Keywords

  • Lactate
  • White Blood Cell
  • Creatine Kinase
  • Muscle Damage
  • Dynamic Variable

Introduction

The muscle-specific inflammatory response after strenuous exercise has some similarity with those observed in sepsis and it is used as a mirror of sepsis-specific inflammatory response. Near-infrared spectroscopy (NIRS) has been used to quantify sepsis-induced metabolic alterations by measuring variations of tissue oxygen saturation (StO2) during a vascular occlusion test (VOT). We aimed to investigate whether NIRS dynamic variables could reflect the magnitude of inflammatory process that follows strenuous exercise in marathon runners.

Methods

VOT-NIRS (InSpectra Model 650) measurement was performed before, at the finish line and on the day after the marathon in 13 runners (10 males/three females). VOT-derived NIRS traces were analyzed for StO2-downslope (RdecStO2) and StO2-upslope (RincStO2). Blood samples were collected to measure C-reactive protein (CRP), procalcitonin (PCT), white blood cells (WBC), creatine kinase (CK), and lactate. Data are mean ± SD (in Table 1, median (IQR)). P < 0.05 was considered statistically significant.
Table 1

NIRS and hemodynamic variables

 

Baseline

End line

Day after

StO2

80 (8.0)

69 (8.0)*

81 (7.0)

RdecStO2

9.5 (7.0)

9.4 (9.0)

13 (7.0)*

RincStO2

4.1 (3.0)

2.3 (3.0)*

4.0 (3.4)

HR

58 (24)

87 (60)*

62 (26)

MAP

93 (14)

88 (29)

87 (20)

Data are median (IQR). *P < 0.05.

Results

The results of NIRS dynamic and hemodynamic variables are shown in Table 1. RdecStO2 was significantly increased in the day after the marathon. Significant increases in lactate (2.7 ± 0.5 vs 1.2 ± 0.3) and WBC (14 × 103 ± 4 vs 5 × 103 ± 2) were observed after the completion of the marathon. Serum CRP, PCT and CK were significantly increased on the day after the marathon (0.6 ± 0.6 vs 12 ± 8; 0.09 ± 0.2 vs 0.7 ± 0.9; 398 ± 198 vs 1,932 ± 1,620), indicating the muscle-specific inflammatory response as a result of muscle damage.

Conclusions

Delayed increase in thenar VO2 is associated with muscle-specific inflammatory response after strenuous exercise as a result of the muscle damage.

Authors’ Affiliations

(1)
Erasmus MC University Medical Centre, Rotterdam, Netherlands
(2)
BRAHMS, Berlin, Germany

Copyright

© BioMed Central Ltd. 2010

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