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Delayed increase in inflammation and thenar VO2 in marathon runners

Introduction

The muscle-specific inflammatory response after strenuous exercise has some similarity with those observed in sepsis and it is used as a mirror of sepsis-specific inflammatory response. Near-infrared spectroscopy (NIRS) has been used to quantify sepsis-induced metabolic alterations by measuring variations of tissue oxygen saturation (StO2) during a vascular occlusion test (VOT). We aimed to investigate whether NIRS dynamic variables could reflect the magnitude of inflammatory process that follows strenuous exercise in marathon runners.

Methods

VOT-NIRS (InSpectra Model 650) measurement was performed before, at the finish line and on the day after the marathon in 13 runners (10 males/three females). VOT-derived NIRS traces were analyzed for StO2-downslope (RdecStO2) and StO2-upslope (RincStO2). Blood samples were collected to measure C-reactive protein (CRP), procalcitonin (PCT), white blood cells (WBC), creatine kinase (CK), and lactate. Data are mean ± SD (in Table 1, median (IQR)). P < 0.05 was considered statistically significant.

Table 1 NIRS and hemodynamic variables

Results

The results of NIRS dynamic and hemodynamic variables are shown in Table 1. RdecStO2 was significantly increased in the day after the marathon. Significant increases in lactate (2.7 ± 0.5 vs 1.2 ± 0.3) and WBC (14 × 103 ± 4 vs 5 × 103 ± 2) were observed after the completion of the marathon. Serum CRP, PCT and CK were significantly increased on the day after the marathon (0.6 ± 0.6 vs 12 ± 8; 0.09 ± 0.2 vs 0.7 ± 0.9; 398 ± 198 vs 1,932 ± 1,620), indicating the muscle-specific inflammatory response as a result of muscle damage.

Conclusions

Delayed increase in thenar VO2 is associated with muscle-specific inflammatory response after strenuous exercise as a result of the muscle damage.

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Correspondence to A Lima.

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Lima, A., Weigel, J., Hoorn, E. et al. Delayed increase in inflammation and thenar VO2 in marathon runners. Crit Care 14, P149 (2010). https://doi.org/10.1186/cc8381

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Keywords

  • Lactate
  • White Blood Cell
  • Creatine Kinase
  • Muscle Damage
  • Dynamic Variable