- Meeting abstract
The lower inflection point of the inspiratory pressure-volume curve overestimates optimal PEEP in surfactant-treated immature lambs
Critical Care volume 4, Article number: P118 (2000)
Static inspiratory pressure-volume (P-V) curves are typically S-shaped with a lower (LIP) and an upper inflection point (UIP), probably because of successive recruitment of lung units. It is often said that PEEP should be set above LIP to avoid derecruitment during expiration. However, as shown in a rabbit model , the effect of PEEP on lung volume is determined by the expiratory part of the P-V loop, which has a markedly different shape.
Eleven lambs with gestational age 119–141 days (term =145 days) delivered by cesarean section were given surfactant and subsequently mechanically ventilated. Using an interrupter technique, static P-V loops were recorded between an end-expiratory pressure of a) 0 cmH2O (ZEEP) or b) 5 cmH2O and an inspiratory pressure of 35 cmH2O.
Loops obtained during insufflation from ZEEP had a large hysteresis; LIP was 16-21 cmH2O, while UIP was above 30 cmH2O, if seen at all (Fig. 1 loop A) and the expiratory limbs showed a high deflation stability down to a pressure of 6-11 cmH2O with a steep segment at lower pressures. Loops from 5 cmH2O had a nearly linear inspiratory limb, and much less hysteresis (Fig. 1 loop B).
In preterm lambs with fully-recruited lung volume, derecruitment can be avoided by a much lower PEEP than indicated by LIP. During mechanical ventilation of immature subjects, the upper inflection point of the expiratory limb (UIPexp) is probably a better indicator of optimal PEEP than LIP of the inspiratory curve.
Rimensberger , et al.: . Crit Care Med 1999, 27: 1946. 10.1097/00003246-199909000-00038
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Ingimarsson, J., Björklund, L., Larsson, A. et al. The lower inflection point of the inspiratory pressure-volume curve overestimates optimal PEEP in surfactant-treated immature lambs. Crit Care 4 (Suppl 1), P118 (2000). https://doi.org/10.1186/cc838