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Pre-ejection period is a reliable parameter to estimate cardiac preload in a hemorrhagic shock
© BioMed Central Ltd. 2010
Published: 1 March 2010
We have already demonstrated that in mechanically ventilated patients, the respiratory change in the pre-ejection period (ΔPEP) is a reliable dynamic index for the prediction of increase in cardiac output after volume infusion . However, in an animal study, Kubitz and colleagues showed that the pre-ejection period is not sensitive to the changes in intravascular volume status .
This study investigated the influence of changes in intravascular volume status on ΔPEP. In 17 pigs, ECG, arterial pressure and cardiac output derived from a Swan-Ganz catheter were recorded. Measurements were performed during normovolaemic conditions, after haemorrhage (25 ml/kg) and following re-transfusion (25 ml/kg) with constant tidal volume (10 ml/kg) and respiration rate (15/minute).
Available correlations between PPV and ΔPEP at each time of the study were observed, meaning that ΔPEP is a reliable parameter to estimate the changes in intravascular volume status.
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