- Poster presentation
- Open Access
Cytokine response in severe sepsis: predicting and modelling the course of illness
© BioMed Central Ltd. 2010
- Published: 1 March 2010
- Severe Sepsis
- Cytokine Response
- ANOVA Model
- Multiorgan Failure
Severe sepsis remains one of the most threatening conditions in intensive care. During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality . These biomarkers were successfully used as predictors in animal studies . Data from humans, especially comparison between children and adults, are limited. Hence, in this study we widely describe systemic cytokine response in this type of patient population.
Prospective study of 37 subjects (20 children, 17 adults) hospitalized with severe sepsis in intensive care. We measured CRP, procalcitonin, TNF, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, TREM-1. ANOVA models were specified using Proc Mixed. Study was fully approved by an ethics committee.
Response of circulating factors in patients with severe sepsis is heterogeneous in the adult and children population and has some distinct features according to the dynamics of CRP, IL-6 and TREM-1.
Supported in part by the Internal Grant Agency of the Ministry of Health NR 9297-3 and NR 9894-4.