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Searching for an ideal hemodynamic marker to predict short-term outcome in cardiogenic shock
Critical Care volume 13, Article number: 1013 (2009)
Cardiogenic shock is a lethal condition. Physicians are searching for hemodynamic markers which could help risk-stratification of patients in this picture. Torgersen and coworkers present an hourly time integral of the cardiac power index and cardiac index drops to predict outcomes in the setting of cardiogenic shock. Continuous monitoring of hemodynamic markers may have a role in prediction of outcomes.
In the previous issue of Critical Care, Torgersen and coworkers present data about careful evaluation of hemodynamic monitoring of patients with cardiogenic shock (CS) in the intensive care unit as continuous variables during the initial 24-hour period . Hemodynamic parameters influencing short-term mortality were identified. The authors stated that hourly time integrals of the cardiac index (CI) (cardiac output per body surface area) and the cardiac power index (CPI) (cardiac power output per body surface area) were the most important hemodynamic variables designating mortality as continuous parameters. In addition, instead of intermittent measures of the CI and the CPI, the authors analyzed the area under a given level divided into hourly intervals, named hourly time integrals. These results have the potential to provide a paradigm shift in the setting of CS.
Two take-home messages can be extracted from the study of Torgersen and coworkers . First is the emphasis on the importance of continuous monitorization in patients with CS, and the second message is providing data for the importance of the interpretation of the CPI as a continuous variable in an acute setting.
CS is traditionally defined as a state of severe tissue hypoperfusion secondary to cardiac dysfunction. It carries high mortality risk, around 50% in the acute term . Therefore, it is vital to identify signals driving the CS prognosis. For decades, hemodynamic monitoring has been desired for patients with acute pathologies with the aim of guiding therapy and risk-stratification . Many parameters derived from hemodynamics - such as the cardiac output, systemic blood pressure, systemic vascular resistance, stroke volume, and pulmonary capillary wedge pressure - have so far been investigated to designate prognosis with unequivocal results [4, 5]. Among these hemodynamic parameters, the cardiac power output and the CPI serve as interesting markers showing cardiovascular coupling at one glance, in contrast to other parameters that provide information about either the cardiac system or the vascular system .
Drops in the CPI were described by Torgersen and colleagues to predict outcome . A critically low CPI might be a result of unresponsiveness to therapeutic interventions rather than a causative factor for death. One should mention that although the hourly time integrals of drops in the CI and CPI predicted short-term mortality, this might not mean that the CI and the CPI are targets for treatment. Indeed, in many cases, patients die despite high CI levels. Intra-aortic balloon pump (IABP) use is known to increase cardiac power output, and hence the CPI . Adjustment should have been performed for the use of an IABP (37.8% of patients). Adjustment for gender was also needed, as the cardiac power output is also lower in females . In a very recent meta-analysis, it was shown that a percutaneous left ventricular assist device yielded higher CI and higher mean arterial pressure compared with the IABP. This could be translated as a higher CPI with the left ventricular assist device compared with that under IABP use. The 30-day mortality was similar in both interventions, however, despite better early hemodynamic status with the left ventricular assist device . A better CI or CPI may therefore not always translate into better outcomes. Torgersen and coworkers brought us some novel thresholds, however, which should be tested in multicenter trials. Eventually, these thresholds can serve as targets.
The present paper emphasizes the continuous effort that should be made to risk-stratify patients with CS. Hemodynamic variables are important to consider in the setting of CS, particularly those parameters integrating generation of cardiac energy with spreading of blood flow, such as the CPI. Since it was shown that almost one-half of nonsurvivors of CS die with a normal CI, this finding changed the paradigm of CS recently from being only a cardiac problem into a disease of the entire circulatory system [9, 10]. Data tell us the importance of systemic inflammatory response upon release of inflammatory mediators and neurohormones yielding alterations in tissue microvasculature, which may result in multi-organ dysfunction syndrome in CS . We therefore agree that hemodynamic signals combining cardiac function with tissue perfusion such as the CPI may be optimal markers of outcome. On the contrary, it might be as important to consider any invasive hemodynamic parameter as a continuous (and not intermittent) marker, as presented by Torgersen and coworkers, instead of considering them per piece.
cardiac power index
intra-aortic balloon pump.
Torgersen C, Schmittinger CA, Wagner S, Ulmer H, Takala J, Jakob SM, Dunser MW: Hemodynamic variables and mortality in cardiogenic shock: a retrospective cohort study. Crit Care 2009, 13: R157. 10.1186/cc8114
Mann HJ, Nolan PE: Update on the management of cardiogenic shock. Curr Opin Crit Care 2006, 12: 431-436. 10.1097/01.ccx.0000244122.62118.da
Zion MM, Balkin J, Rosenmann D, Goldbourt U, Reicher-Reiss H, Kaplinsky E, Behar S, for the SPRINT Study Group: Use of pulmonary artery catheters in patients with acute myocardial infarction. Chest 1990, 98: 1331-1335. 10.1378/chest.98.6.1331
Hasdai D, Holmes DR Jr, Califf RM, Thompson TD, Hochman JS, Pfisterer M, Topol EJ: Cardiogenic shock complicating acute myocardial infarction: predictors of death. GUSTO Investigators. Global Utilization of Streptokinase and Tissue-Plasminogen Activator for Occluded Coronary Arteries. Am Heart J 1999, 138: 21-31. 10.1016/S0002-8703(99)70241-3
Cotter G, Moshkovitz Y, Kaluski E, Milo O, Nobikov Y, Schneeweiss A, Krakover R, Vered Z: The role of cardiac power and vascular resistance in the pathophysiology, diagnosis and treatment of patients with congestive heart failure, pulmonary edema and cardiogenic shock. Eur J Heart Fail 2003, 5: 443-451. 10.1016/S1388-9842(03)00100-4
Mueller H, Ayres SM, Gianelli S, Conklin EF, Mazzara JT, Grace WJ: Effect of isoproterenol, L-norepinephrine, and intraaortic counterpulsation on hemodynamics and myocardial metabolism in shock following acute myocardial infarction. Circulation 1972, 45: 335-351.
Fincke R, Hochman JS, Lowe AM, Menon V, Slater JN, Webb JG, LeJemtel TH, Cotter G, SHOCK Investigators: Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry. J Am Coll Cardiol 2004, 44: 340-348. 10.1016/j.jacc.2004.03.060
Cheng JM, den Uil CA, Hoeks SE, Ent M, Jewbali LS, van Domburg RT, Serruys PW: Percutaneous left ventricular assist devices vs. intra-aortic balloon pump counterpulsation for treatment of cardiogenic shock: a meta-analysis of controlled trials. Eur Heart J 2009, 30: 2102-2108. 10.1093/eurheartj/ehp292
Lim N, Dubois MJ, De Backer D, Vincent JL: Do all nonsurvivors of cardiogenic shock die with a low cardiac index? Chest 2003, 124: 1885-1891. 10.1378/chest.124.5.1885
Reynolds HR, Hochman JS: Cardiogenic shock, current concepts and improving outcomes. Circulation 2008, 117: 686-697. 10.1161/CIRCULATIONAHA.106.613596
De Backer D, Creteur J, Dubois MJ, Sakr Y, Vincent JL: Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 2004, 147: 91-99. 10.1016/j.ahj.2003.07.006
The authors declare that they have no competing interests.
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Yilmaz, M.B., Mebazaa, A. Searching for an ideal hemodynamic marker to predict short-term outcome in cardiogenic shock. Crit Care 13, 1013 (2009). https://doi.org/10.1186/cc8176
- Cardiac Index
- Cardiogenic Shock
- Hemodynamic Parameter
- Pulmonary Capillary Wedge Pressure
- Hemodynamic Monitoring