- Open Access
RIFLE is not RIFLE: on the comparability of results
Critical Care volume 13, Article number: 429 (2009)
In the consensus RIFLE criteria  of acute kidney injury (AKI) the thresholds given for serum creatinine (sCr) increase and glomerular filtration rate (GFR) decrease (Table 1) do not correspond . Direct measurement of GFR in clinical practice is difficult, and values are more often estimated (eGFR) by the Cockroft-Gault equation or the Modification of Diet in Renal Disease (MDRD) formula. In addition, there is controversy in the literature whether eGFR provides more clinical information regarding AKI than changes in sCr .
As an example of the possible discrepancy, a 1.5-fold increase (50%) in sCr from a baseline of 1.0 mg/dL in a 60-year-old white male corresponds to only a 37% eGFR decrease using the MDRD formula. In this scenario the patient is classified in RIFLE class R by both methods. In the same patient an only 30% increase in sCr (1.0 mg/dL to 1.3 mg/dL), however, corresponds to a 26% decrease of eGFR. Therefore, the patient would consequently be classified as having AKI in RIFLE class R by the GFR threshold but not based on sCr changes. This theoretical disagreement in defining and staging AKI by RIFLE has been outlined previously , but data to estimate potential discrepancy in a 'real world' scenario are not available.
Furthermore, the use of different versions of RIFLE criteria counteracts the original goal of a consensus definition and hinders comparability.
To understand the differences better, we applied these two methods of calculating RIFLE to consecutive patients undergoing cardiac surgery with cardiopulmonary bypass between 2005 and 2007 at our institution. AKI was defined by using either largest sCr increase or eGFR decrease (MDRD formula) within the first postoperative week compared to baseline. In all patients a preoperative baseline sCr was available. We did not use urine output criteria to define AKI.
Among the total cohort, 9.3% patients were diagnosed as having AKI by the sCr criteria versus 18.9% with eGFR criteria (Table 2). The largest disagreement was detected in class R. Overall, the diagnosis of AKI using eGFR thresholds was more sensitive than sCr changes, and this was also true for staging of patients in RIFLE classes R and I. However, for patients staged in the highest AKI class F, sensitivity was higher for sCr criteria. These discrepancies can be expected to be found in other patient populations when non-uniform methods of determining RIFLE criteria are utilized. Our findings may assist in interpretation of other clinical studies.
Recently the RIFLE criteria have been modified by the Acute Kidney Injury Network (AKIN) , and the change in eGFR is no longer included in this consensus definition set. RIFLE criteria calculated by both methods remain widely used and the process of comparison between the two definition schemes (RIFLE and AKIN) in various patient populations is not yet complete. Further validation is required and modifications in the definition and staging of AKI can be expected .
acute kidney injury
Acute Kidney Injury Network
glomerular filtration rate
Modification of Diet in Renal Disease
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8: R204-212. 10.1186/cc2872
Pickering JW, Endre ZH: GFR shot by RIFLE: errors in staging acute kidney injury. Lancet 2009, 373: 1318-1319. 10.1016/S0140-6736(09)60751-0
Lippi G, Guidi GC: Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate? Crit Care 2008, 12: 423. author reply 423 10.1186/cc6936
Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007, 11: R31. 10.1186/cc5713
Cruz DN, Ricci Z, Ronco C: Clinical review: RIFLE and AKIN - time for reappraisal. Crit Care 2009, 13: 211. 10.1186/cc7759
The authors declare that they have no competing interests.
About this article
Cite this article
Englberger, L., Suri, R.M. & Schaff, H.V. RIFLE is not RIFLE: on the comparability of results. Crit Care 13, 429 (2009). https://doi.org/10.1186/cc8175
- Glomerular Filtration Rate
- Acute Kidney Injury
- Consensus Definition
- Acute Kidney Injury Network
- Rifle Criterion