Volume 1 Supplement 1

17th International Symposium on Intensive Care and Emergency Medicine

Open Access

Optimisation of high risk surgical patients improves mortality in clinical practice

  • A Rhodes1,
  • FJ Lamb1,
  • PJ Newman1,
  • RM Grounds1 and
  • ED Bennett1
Critical Care19971(Suppl 1):P097

https://doi.org/10.1186/cc81

Published: 1 March 1997

Introduction

Deliberately increasing oxygen delivery (DO2) in the peri-operative period has been shown to improve survival for high risk surgical patients, in several randomised, controlled, trails [1].

Design, subjects and methods

A prospective study evaluating the efficacy of increasing peri-operative oxygen delivery in high risk surgical patients, to greater than 600 ml/min/m2 with dopexamine hydrochloride, in routine clinical practice

Results

Expressed as medians with 25%, 75% centiles.

Conclusions

An 11.9% 28 day mortality rate compares favourably with historical controls and clinical trials. This study confirms that the technique of increasing DO2 in the peri-operative period is both practical and beneficial in routine clinical practice.

Table

Number of patients

50

Age years

72 (64, 76)

Sex male/female (%)

62/38

Number of high risk criteria

1.9

APACHE III score

65 (50, 80)

Admitted pre-op/postop (%)

88/12

Elective emergency (%)

54/46

Baseline DO2

492 (439, 562)

Pre-operative DO2

639 (522, 693)

Postoperative DO2

488 (368, 735)

Number of patients achieving DO2 > 600 ml/min/m2

25

Number of patients achieving DO2 > 600 ml/min/m2 without dopexamine

12

ICU length of stay days

2.8 (2, 6.3)

Hospital length of stay days

24 (12, 48)

Mortality prediction ratio from APACHE III (%)

31(7,50)

28 Day mortality rate (%)

11.9

Authors’ Affiliations

(1)
Department of Intcnsive Care Medicine, St George's Hospital

References

  1. Boyd O, Grounds RM, Bennett ED: . JAMA. 1993, 270: 2699-2707. 10.1001/jama.270.22.2699.PubMedView ArticleGoogle Scholar

Copyright

© Current Science Ltd 1997

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