Volume 13 Supplement 3

Fifth International Symposium on Intensive Care and Emergency Medicine for Latin America

Open Access

Effect of magnesium on prophylaxis of vasospasm, morbidity, and mortality in subarachnoid hemorrhage patients

  • SK Macedo1,
  • RM Nuss1,
  • S Pereira1,
  • CMPD Siqueira1,
  • SBPD Siqueira1 and
  • DP Lima1
Critical Care200913(Suppl 3):P54

https://doi.org/10.1186/cc7856

Published: 23 June 2009

Introduction

We propose this study in order to reach two end points: (a) vasospasm clinical incidence, confirmed by CT; and (b) the mortality of these patients in 28 days. The study shows a comparison of a group of patients that used Mg (Intervention Group 1) from those that did not (Control Group 2).

Methods

After institutional approval and informed consent, a prospective, randomized, nonblind study was performed between February and November 2008. The main goal of the study was to achieve a Mg serum concentration from 2.5 to 3.5 mg/dl, using a solution of Mg 2% (SG 5% 400 ml + MgSO4 10% 100 ml/24 hours), during the first 14 days of aneurysm rupture. Admission criteria: patients diagnosed with SAH and Δt <96 hours. Exclusion criteria: patients with SAH and Δt >96 hours.

Results

In a previous study evaluation we analysed a total of 56 patients, with 26 in Group 1 and 30 in Group 2 (Tables 1 and 2). Main results: Group 1 – vasospasm frequency 26.9% (n = 7) and mortality 19.2% (n = 5) in 28 days; Group 2 – vasospasm frequency 46.7% (n = 14) and mortality 33.3% (n = 10) in 28 days.
Table 1

(abstract P54)

 

APACHE II

Average Mg level

Group I (n = 26)

8.2

2.32

Group II (n = 30)

15.6

1.9

Table 2

(abstract P54)

 

Group I (n = 26)

Group II (n = 30)

 
 

Freq. (% (n))

95% CI

OR

Freq. (% (n))

95% CI

OR

P value

Vasospasm

26.9 (7)

11.6 to 47.8

0.4

46.7 (14)

28.3 to 65.7

1

0.1

Mortality in 28 days

19.2 (5)

6.6 to 39.4

0.5

33.3 (10)

17.3 to 52.8

1

0.2

CI, confidence interval; Freq., frequency; OR, odds ratio.

Conclusion

According to the outcome, we can conclude that Group 1 obtained a greater protection for vasospasm incidence and a decrease of mortality in comparison with Group 2. The P value was not significant due to a still small number of patients.

Authors’ Affiliations

(1)
Hospital São José Do Avaí

Copyright

© BioMed Central Ltd 2009

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