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Lactate generation is not related to tissue partial pressure of oxygen levels in sepsis
Critical Care volume 13, Article number: P5 (2009)
To analyze behavior of tissue partial pressure of oxygen (pO2) measured in the liver during sepsis and to correlate its reduction with lactate levels.
Eleven large white pigs, weight 35 kg, in general anesthesia (isofluorane, fentanyl, pancuronium), fully monitored (electrocardiography, etCO2, invasive pressure, pulmonary artery catheter, portal vein Doppler ultrasound flow, small bowel tonometry), were submitted to fecal peritonitis sepsis (1 g/kg feces plus 150 ml warm saline) after pO2 and laser Doppler fluxometry probes were placed inside liver parenchyma. Laboratory and hemodynamic data were registered hourly. After the experiments, pigs were sacrificed with sedative overdose and KCl 19.1% injection.
Lactate generation not only seems to be related to tissue hypoxia in septic pigs. Inflammation and mitochondrial dysfunction may probably play a role in this pathological process. Further studies are needed to clarify these mechanisms. Perhaps other interventions, not only oxygen uptake optimization, ought to be necessary for early reversal of septic cascade.
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Pereira, A., Rehder, P., Dias, C. et al. Lactate generation is not related to tissue partial pressure of oxygen levels in sepsis. Crit Care 13 (Suppl 3), P5 (2009). https://doi.org/10.1186/cc7807