Open Access

Colloid-induced kidney injury: experimental evidence may help to understand mechanisms

Critical Care200913:130

https://doi.org/10.1186/cc7745

Published: 3 April 2009

Abstract

Fluid resuscitation is widely used, and many patients are therefore exposed to plasma volume expanders. Among these, colloids, particularly hydroxyethyl starches, have been shown in recent experiments and clinical studies to induce acute kidney injury. The mechanisms of colloid-induced acute kidney injury remain incompletely elucidated. The risks associated with colloid osmotic pressure elevation in vivo and the high incidence of osmotic nephrosis lesions in experimental models and clinical studies indicate that hydroxyethyl starches can no longer be considered safe.

Plasma volume expansion is often required in the operating room, emergency department, or intensive care unit. The safety of plasma volume expanders therefore deserves careful consideration. Low renal perfusion is a major risk factor for acute kidney injury (AKI), and plasma volume expansion is therefore crucial for its prevention. On the contrary, among plasma volume expanders, colloids can induce kidney injury, as shown many years ago [15]. Recent experiments and clinical studies have supplied further information on the renal toxicity of some colloids, particularly hydroxyethyl starches (HESs) [69].

Colloid-induced AKI with morphological abnormalities of the proximal tubular cells, or osmotic nephrosis, has been reported after the infusion of low-molecular-weight dextran or, more recently, HES. The tubular lesions reflect the accumulation of proximal tubular lysosomes due to pinocytosis of exogenous osmotic solutes (for example, mannitol, sucrose, iodinated contrast media, or colloids) [10]. The tubular cells swell because they contain numerous lysosomes and endocytotic vacuoles. Furthermore, the oncotic force of colloids may induce further renal function impairment by decreasing the renal filtration pressure [3]. The exact mechanisms of colloid-induced AKI remain incompletely elucidated, and controversy exists regarding the relative roles for morphological and functional changes [4].

Because HESs are widely used and AKI is strongly associated with decreased survival, the risk of AKI associated with various HESs needs to be determined. Three generations of HES have been developed over time. Newer HESs have lower molecular weight and lower degree of substitution, two changes that should decrease accumulation and toxicity [11]. Third-generation HESs have molecular weights lower than 200 kDa and degrees of hydroxyl substitution lower than 0.5, the most common combination being 130/0.4. First-generation and second-generation HESs have been found to induce AKI in heart surgery patients, in brain-dead organ donors, and in patients with sepsis [6, 7, 9, 12]. The most recent randomized controlled trial, which included a large number of patients, showed a higher incidence of AKI with 10% HES 200/0.5 than with Ringer lactate solution in intensive care unit patients with sepsis [6]. Both the administration of large volumes and high in vitro colloid osmotic pressure (COP) may contribute to renal toxicity. No large randomized controlled trial establishing the safety of third-generation HESs is available.

In the previous issue of Critical Care, Hüter and coworkers report an interesting experiment aimed at improving our understanding of HES-induced AKI [1]. Using hemodilution in a model of isolated kidney perfusion, they assessed the renal effects of one second-generation HES solution and one third-generation HES solution comparative to a crystalloid. Although their model was very different from the clinical situation, and the number of studied animals was limited, morphological studies of the kidneys yielded useful information. After in vivo hemodilution, creatinine clearance was higher with the crystalloid than with either HES. As expected, the glomerular filtration pressure was much higher with the crystalloid. For a similar mean arterial pressure, the COP was considerably lower after crystalloid infusion and was similarly increased with both HESs. Although the two HESs had different in vitro COP values, their in vivo COP effect was similar. The rapid in vivo degradation of HES 130/0.4 usually results in a high plasma COP, as illustrated here. After isolated kidney perfusion, the plasma COP remained similar in the two HES groups, but creatinine clearance was lower with the second-generation 10% HES 200/0.5. This result suggests an additional role for a delayed decrease in glomerular filtration, independent of filtration pressure. Morphological examination showed that the lesions of osmotic nephrosis were more severe in the two HES groups, despite the limited volumes infused. Tubular lesions appeared as early as 6 hours after exposure and were associated with greater severity of the interstitial inflammation and tubular dysfunction in the 10% HES 200/0.5 group.

The results of this experiment have implications for clinical practice. First, the in vivo COP of the fluid used may have an early effect on the glomerular filtration pressure, as recently suggested in patients resuscitated for shock [8]. With polydispersed macromolecules such as HES, the in vivo COP differs from the in vitro COP. Also, third-generation HESs can induce osmotic nephrosis similar to that seen with older compounds, within a few hours of exposure. Recent systematic reviews have alerted clinicians to the renal toxicity of HES [13, 14]. In the absence of large randomized controlled trials, doubts about the safety of third-generation HES persist, and the results reported by Hüter and colleagues leave room for concern about the safety of widespread use of third-generation HES. Furthermore, HESs have been reported to induce not only AKI, but also irreversible chronic renal failure [10, 15, 16].

The question therefore is should HESs or other colloids ever be used for fluid resuscitation? There is no evidence from randomized controlled trials that colloids improve patient outcomes [17]. Thousands of patients included in randomized controlled trials have been safely resuscitated using only crystalloids [17]. Furthermore, the study by Hüter and coworkers shows that colloid toxicity and the risk of colloid-induced AKI can be assessed experimentally before colloids are considered for use in humans.

Abbreviations

AKI: 

acute kidney injury

COP: 

colloid osmotic pressure

HES: 

hydroxyethyl starch.

Declarations

Authors’ Affiliations

(1)
AP-HP,, Réanimation Médicale, F-94000, Groupe Hospitalier Albert Chenevier – Henri Mondor
(2)
Faculté de Médecine, F-94000, Université Paris 12
(3)
Faculté de Médecine,F-94000, INSERM

References

  1. Hüter L, Simon T, Weinmann L, Schuerholz T, Reinhart K, Wolf G, Amann K, Marx G: Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model. Crit Care 2009, 13: R23. 10.1186/cc7726PubMed CentralView ArticlePubMedGoogle Scholar
  2. Janssen CW Jr: Osmotic nephrosis. A clinical and experimental investigation. Acta Chir Scand 1968, 134: 481-487.PubMedGoogle Scholar
  3. Moran M, Kapsner C: Acute renal failure associated with elevated plasma oncotic pressure. N Engl J Med 1987, 317: 150-153.View ArticlePubMedGoogle Scholar
  4. Druml W, Polzleitner D, Laggner AN, Lenz K, Ulrich W: Dextran-40, acute renal failure, and elevated plasma oncotic pressure. N Engl J Med 1988, 318: 252-254.Google Scholar
  5. Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet 2004, 363: 1988-1996. 10.1016/S0140-6736(04)16415-5View ArticlePubMedGoogle Scholar
  6. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, the German Competence Network S: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008, 358: 125-139. 10.1056/NEJMoa070716View ArticlePubMedGoogle Scholar
  7. Cittanova ML, Leblanc I, Legendre C, Mouquet C, Riou B, Coriat P: Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients. Lancet 1996, 348: 1620-1622. 10.1016/S0140-6736(96)07588-5View ArticlePubMedGoogle Scholar
  8. Schortgen F, Girou E, Deye N, Brochard L: The risk associated with hyperoncotic colloids in patients with shock. Intensive Care Med 2008, 34: 2157-68. 10.1007/s00134-008-1225-2View ArticlePubMedGoogle Scholar
  9. Schortgen F, Lacherade JC, Bruneel F, Cattaneo I, Hemery F, Lemaire F, Brochard L: Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet 2001, 357: 911-916. 10.1016/S0140-6736(00)04211-2View ArticlePubMedGoogle Scholar
  10. Dickenmann M, Oettl T, Mihatsch MJ: Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes. Am J Kidney Dis 2008, 51: 491-503. 10.1053/j.ajkd.2007.10.044View ArticlePubMedGoogle Scholar
  11. Boldt J, Suttner S: Plasma substitutes. Minerva Anestesiol 2005, 71: 741-758.PubMedGoogle Scholar
  12. Winkelmayer WC, Glynn RJ, Levin R, Avorn J: Hydroxyethyl starch and change in renal function in patients undergoing coronary artery bypass graft surgery. Kidney Int 2003, 64: 1046-1049. 10.1046/j.1523-1755.2003.00186.xView ArticlePubMedGoogle Scholar
  13. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hebert P, Bagshaw S, Monsour D, McIntyre L: Renal outcomes following hydroxyethl starch resuscitation: a meta-analysis of randomized trials [abstract]. Intensive Care Med 2008,34(Suppl 1):A0345.Google Scholar
  14. Wiedermann CJ: Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis. BMC Emerg Med 2008, 8: 1-8. 10.1186/1471-227X-8-1PubMed CentralView ArticlePubMedGoogle Scholar
  15. Pillebout E, Nochy D, Hill G, Conti F, Antoine C, Calmus Y, Glotz D: Renal histopathological lesions after orthotopic liver transplantation (OLT). Am J Transplant 2005, 5: 1120-1129. 10.1111/j.1600-6143.2005.00852.xView ArticlePubMedGoogle Scholar
  16. Jamal R, Ghannoum M, Naud J-F, Turgeon P-P, Leblanc M: Permanent renal failure induced by pentastarch. NDT Plus 2008, 1: 322-325. 10.1093/ndtplus/sfn075PubMed CentralPubMedGoogle Scholar
  17. Perel P, Roberts I: Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2007, 4: CD000567.PubMedGoogle Scholar

Copyright

© BioMed Central Ltd 2009

Advertisement