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Is smaller high enough? Another piece in the puzzle of stress, strain, size, and systems


Extracorporeal lung-supporting procedures open the possibility of staying within widely accepted margins of 'protective' mechanical ventilation (tidal volume of less than 6 mL per kg of predicted ideal body weight and plateau pressure of less than 30 cm H2O) in most any case of respiratory failure or even of further reducing ventilator settings while still providing adequate gas exchange. There is evidence that, at least in some patients, a further reduction in tidal volumes might be beneficial. Extracorporeal procedures to support the lungs have undergone tremendous technical developments, thus reducing the procedure-related risks. However, what is true for ventilator settings should also be true for extracorporeal procedures: studies will have to demonstrate a convincing risk-benefit ratio. In addition, a simple reduction of the tidal volume will certainly not be the right answer. If extracorporeal support largely influences gas exchange, the 'optimal' tidal volume/positive end-expiratory pressure ratio keeping stress and strain low and avoiding alveolar derecruitment will still have to be individually defined.

In the previous issue of Critical Care, Zimmermann and colleagues [1] published a prospective observational study in which they applied a pumpless extracorporeal support system to improve gas exchange in a series of 51 patients still fulfilling acute respiratory distress syndrome (ARDS) criteria after 24 hours of 'advanced' respiratory support including low tidal volume ventilation (<6 mL/kg) as well as positive end-expiratory pressure (PEEP) settings according to the ARDSNet 'high-PEEP' table. Positioning was performed either as prone positioning or as continuous lateral rotation therapy (CLRT), balanced volume therapy, and infection control [1, 2]. The device consisted simply of two cannulas, a short tubing system, and an oxygenator. Such a system uses the individual cardiac output and resulting mean arterial blood pressure in an arteriovenous setting as the driving force. The principle is called pumpless ECMO (extra-corporeal membrane oxygenation), spontaneous arteriovenous carbon dioxide removal, or interventional lung assist, the last of which represents the 'official' labeling of the company providing the commercially available set used in this study. In brief, Zimmermann and colleagues were able to demonstrate efficient carbon dioxide removal at markedly reduced respiratory settings after 2 hours and even more so after 24 hours. The use of a well-defined algorithm including a restriction of the cannula size used for arterial cannulation decreased the number of ischemic complications when compared with two preceding studies of the same group in which a consistent rate of 10% ischemic complications was reported.

The study of Zimmermann and colleagues has evident limitations: lack of a control group and/or randomization, single-center performance, introduction and evaluation of several interventions at the same time, and, in addition, lack of clear definitions for terms like balanced volume therapy or infection control. Even so, this does not narrow the importance of these findings. On the contrary, looking at these data as a work in progress, we can draw several important conclusions.

First, no matter what kind of extracorporeal lung support is used, there is evidence that these procedures should represent well-defined steps in an escalating algorithm of acute lung injury/ARDS treatment. As stress triggered by mechanical ventilation is finally determined by the resulting trans-pulmonary pressures transmitted by each breath (whereas strain is related to the ratio between end-expiratory lung volume and the applied tidal volume), smaller tidal volumes in combination with an adequate level of PEEP (balancing the ratio between tidal volume and end-expiratory lung volume) should increase protectiveness of mechanical ventilation and ideally reduce mortality [35]. Recent experimental work by Dembinski and colleagues [6] demonstrated that a tidal volume reduction at the same level of PEEP led to a marked increase in shunt and low ventilation-perfusion (VA/Q) areas, indicating sustained derecruitment of the lungs. This phenomenon has also been demonstrated in the clinical setting by Richard and colleagues [7] in ARDS patients while reducing the tidal volume from 10 to 6 mL. The application of lower tidal volumes obviously requires higher PEEP to avoid alveolar derecruitment. In addition, in the context of extracorporeal gas exchange, the weakness of the concept of setting PEEP according to a table becomes evident, and in the present study, what is very probably a 'false' PEEP reduction (obviously triggered by the increase in the PaO2/FiO2 [arterial partial pressure of oxygen/fraction of inspired oxygen] ratio after interventional lung assist insertion) was induced after 2 hours and had to be corrected after 24 hours.

Second, cannula size matters when an arterial vascular access is required. Even when the complication rate while using cannula sizes of less than 17 Fr was reduced to 5.9% in the present study, it still remains high, possibly too high when this approach is used to achieve further 'protectiveness' during mechanical ventilation [8, 9]. There is some evidence and personal experience that the restriction of cannula sizes to 15 Fr or less minimizes the risk to a negligible level. Ideally, however, one venous double-lumen cannula would ensure the vascular access, and a small pump that is very easy to handle may be integrated into the system as a single-use product, delivering the flow in the range needed in a given case. For evident reasons, the simple rule 'the smaller, the better' is not true. Smaller tidal volumes require an individually adapted higher PEEP or continuous positive airway pressure (CPAP) level and a lot of experimental and clinical research to describe how an optimized individual tidal volume/PEEP setting can be defined while using a 'safe' extracorporeal lung support system that enables gas exchange.



acute respiratory distress syndrome


positive end-expiratory pressure.


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Correspondence to Michael Quintel.

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MQ is a member of the advisory board of Novalung GmbH (Talheim, Germany) and therefore has received advisor honoraria. OM declares that he has no competing interests.

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Quintel, M., Moerer, O. Is smaller high enough? Another piece in the puzzle of stress, strain, size, and systems. Crit Care 13, 126 (2009).

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