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Effects of mercaptoethylguanidine during long-term hyperdynamic porcine endotoxemia
Critical Care volume 4, Article number: P51 (2000)
Excess NO production due to iNOS activation and cellular toxicity resulting from peroxynitrite (ONOO-) may contribute to organ dysfunction in septic shock. Therefore, we studied the effect of the combined ONOO-scavenger and selective iNOS-inhibitor mercaptoethylguanidine (MEG)  on hepato-splanchnic hemodynamics and energy metabolism during long-term hyperdynamic porcine endotoxemia .
12 h after starting continuous intravenous endotoxin, pigs received either no drug (CNT; n=9) or 3 mg/kg/h MEG (n=7). Hydroxyethyl starch was infused to maintain a sustained increase in cardiac output . Before, as well as 12, 18, and 24 h after, the start of LPS we assessed expired NO formation (chemiluminescence), systemic (CO) and liver (Doppler ultrasound flow probes) blood flow, arterial-ileal mucosal PCO2-gap (fiberoptic sensor), portal (pv) and hepatic venous (hv) lactate/pyruvate (L/P) ratios and hepatic lactate clearance.
MEG allowed for hemodynamic stabilization due to blunting of the progressive endotoxin-induced fall in MAP while maintaining CO but did not influence the parameters of hepato-splanchnic energy metabolism. Ongoing oxidative stress resulting from inadequate dosage of the compound may account for this result .
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Supported by Provinz Bozen-Südtirol (Italy), ESICM and Deutsche Forschungsgemeinschaft.
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Ploner, F., Tugtekin, I., Matejovic, M. et al. Effects of mercaptoethylguanidine during long-term hyperdynamic porcine endotoxemia. Crit Care 4, P51 (2000). https://doi.org/10.1186/cc771
- Hemodynamic Stabilization
- Hydroxyethyl Starch
- Flow Probe