Table 2 incidence known risk factors for CIP/CIM, occurring during ICU stay
Total population n = 620 | Surgical ICU n = 476 | Medical ICU n = 144 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Before IIT n = 168 | After IIT n = 452 | p- value | Before IIT n = 62 | After IIT n = 414 | p-value | Before IIT n = 106 | After IIT n = 38 | p-value | |
Treatment with noradrenaline | |||||||||
Treated patients, total n (%) | 84/142 (59.2) | 345/399 (86.5) | < 0.0001 | 37/53 (69.8) | 319/366 (87.2) | < 0.0001 | 47/89 (52.8) | 26/33 (78.8) | 0.007 |
Number of days treatment, median (IQR) | 2(0 to 9) | 8 (3 to 16) | < 0.0001 | 6(0 to 15) | 9(4 to 17) | 0.03 | 1(0 to 6) | 9(4 to 17) | 0.03 |
Treatment with aminoglycosides | |||||||||
Treated patients, total n (%) | 45/142 (31.7) | 82/399 (20.6) | 0.007 | 14/53 (26.4) | 76/366 (20.8) | 0.3 | 31/89 (34.8) | 6/33 (18.2) | 0.08 |
Number of days treatment, median (IQR) | 0 (0 to 1) | 0 (0 to 0) | 0.08 | 0 (0 to 1) | 0 (0 to 0) | 0.5 | 0 (0 to 1) | 0 (0 to 0) | 0.2 |
Treatment with glucocorticoids | |||||||||
Treated patients, total n (%) | 93/142 (65.5) | 201/399 (50.4) | 0.002 | 30/53 (56.6) | 177/366 (48.4) | 0.3 | 63/89 (70.8) | 24/33 (72.7) | 0.04 |
Number of days treatment, median (IQR) | 4.5 (0 to 12) | 1 (0 to 11) | 0.02 | 1(0 to 12) | 0(0 to 11) | 0.6 | 6(0 to 12) | 5(0 to 11) | 0.6 |
Cumulative dose hydrocortisone equivalent mg (IQR) | 945 (0 to 4350) | 50 (0 to 2100) | 0.001 | 300 (0 to 3009) | 0 (0 to 1725) | 0.3 | 1125 (0 to 5181) | 833 (0 to 2695) | 0.3 |
Treatment with NMBA | |||||||||
Treated patients prolonged (min 3d bolus or drip) total n (%) | 37/142 (26.1) | 129/399 (32.3) | 0.2 | 15/53 (28.3) | 121/366 (33.1) | 0.5 | 22/89 (24.7) | 8/33 (24.2) | 0.9 |
Number of days treatment at least 1 bolus or drip, median (IQR) | 1 (0 to 3) | 2 (1 to 4) | 0.006 | 2 (0 to 4) | 2 (1 to 4) | 0.6 | 1 (0 to 3) | 1 (0 to 2) | 0.8 |
Dialysis, | |||||||||
Yes | 41/142 (28.9) | 149/399 (37.3) | 0.07 | 18/53 (34.0) | 142/366 (38.8) | 0.5 | 23/89 (25.8) | 7/33 (21.2) | 0.6 |
d, median (IQR) | 0 (0 to 3) | 0 (0 to 9) | 0.06 | 0 (0 to 9) | 0 (0 to 11) | 0.6 | 0 (0 to 1) | 0 (0 to 0) | 0.7 |
Bacteraemia, yes, total n (%) | 54/142 (38.0) | 135/399 (33.8) | 0.4 | 24/53 (45.3) | 119/366 (32.5) | 0.07 | 30/89 (33.7) | 16/33 (48.5) | 0.1 |
Time to diagnosis, days median (IQR) | 18 (12 to 28) | 21 (13 to 32) | 0.01 | 21 (15 to 34) | 22 (14 to 32) | 0.7 | 15 (9 to 25) | 12 (8 to 18) | 0.2 |