Volume 13 Supplement 1

29th International Symposium on Intensive Care and Emergency Medicine

Open Access

Use of deferred proxy consent in two emergency critical care trials

  • E Kompanje1,
  • T Jansen1,
  • J Le Noble1,
  • H De Geus1 and
  • J Bakker1
Critical Care200913(Suppl 1):P488

https://doi.org/10.1186/cc7652

Published: 13 March 2009

Introduction

Almost all patients with life-threatening conditions are incapacitated to give informed consent for participation in emergency critical care research. Deferred proxy consent (DPC) is an ethically valid surrogate for informed patient consent. Here we present our experience in two emergency trials [1].

Methods

We analysed the use of DPC in the Early Lactate-directed Therapy in Intensive Care Trial (NCT 00270673) and the NGAL study (TC 1405).

Results

In the lactate-directed therapy trial, 362 patients were randomized. In 75.4% DPC could be obtained, 3.9% of the relatives refused DPC and in 20.7% DPC could not be obtained before the end of the study (= 72 hours). In the NGAL study, 550 patients were randomized. DPC or patient consent was obtained in 89.8%, 0.7% refused DPC and in 9.4% DPC could not be obtained due to early patient death. In both studies combined, only in 2% was DPC refused and in 10% consent could not be obtained due to early patient death.

Conclusion

DPC is an ethically valid and practically feasible way to include patients in emergency critical care trials.

Authors’ Affiliations

(1)
Erasmus MC University Medical Center

References

  1. Jansen TC, Kompanje EJO, Druml C, Menon D, Wiedermann CJ, Bakker J: Deferred consent in emergency research: what if the patient dies early? Use the data or not? Intensive Care Med 2007, 33: 894-900. 10.1007/s00134-007-0580-8View ArticleGoogle Scholar

Copyright

© Kompanje et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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