Volume 13 Supplement 1
Impact of hypernatremia, hyponatremia and their comparison on ICU mortality
© Mokhtari et al; licensee BioMed Central Ltd. 2009
Published: 13 March 2009
We studied 274 patients hospitalized in a general ICU of a major teaching hospital in Tehran, Iran, cross-sectionally, between 2004 and 2006. Patients' biographical data, reasons for admission, hyponatremia (sodium less than 135 mEq/l) and hypernatremia (sodium more than 145 mEq/l) during the ICU stay were recorded and their effects on mortality were assessed.
The mortalities of patients with hyponatremia (34.33% versus 15.37% with OR = 5.69 and 95% CI from 2.87 to 11.30) and with hypernatremia (55.17% versus 17.78% with OR = 2.80 and 95% CI from 1.43 to 5.49) were significantly higher than patients without it. The mean age of patients with sodium imbalance was higher compared with those without it (hypo-natremia and hypernatremia 52.25 ± 21.12 vs. 44.40 ± 20.28 years and 55.59 ± 19.69 vs. 48.52 ± 21.83 years, respectively). Mortality was significantly higher in hypernatremic compared with hyponatremic patients (55.2% vs. 34.3%, respectively, 95% CI from 7.7% to 33.9%; P = 0.0034).
Serum sodium imbalances carry unacceptably high mortality . Patients with hypernatremia showed higher ICU mortality as compared with those with hyponatremia.
- Kraft MD, Btaiche IF, Sacks GS, Kudsk KA: Treatment of electrolyte disorders in adult patients in the intensive care unit. Am J Health Syst Pharm 2005, 62: 1663-1682. 10.2146/ajhp040300View ArticleGoogle Scholar
- Zilberberg MD, Exuzides A, Spalding J, Foreman A, Jones AG, Colby C, et al.: Epidemiology, clinical and economic outcomes of admission hyponatremia among hospitalized patients. Curr Med Res Opin 2008, 24: 1601-1608. 10.1185/03007990802081675View ArticleGoogle Scholar
- Patel GP, Balk RA: Recognition and treatment of hyponatremia in acutely ill hospitalized patients. Clin Ther 2007, 29: 211-229. 10.1016/j.clinthera.2007.02.004View ArticleGoogle Scholar
- Lindner G, Funk GC, Schwarz C, Kneidinger N, Kaider A, Schneeweiss B, et al.: Hypernatremia in the critically ill is an independent risk factor for mortality. Am J Kidney Dis 2007, 50: 952-957. 10.1053/j.ajkd.2007.08.016View ArticleGoogle Scholar
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